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MAPK cell signal transduction pathways determine the survival of the cells. If one can control this pathways, and then they will prohibit the proliferation of the cancer cells. Furthermore, they will heal the cancer smoothly. In order to attain this goal, we use lots of drugs to interact with MEK1 in MAPK, by using computer aided drug design to analyze the ligand activity of proteins in MEK1.
This research is to develop a system to allow cancer researchers as well as drug discovery people to study drug effects in situ, real-time and at "few cells" level but large cell numbers. A microelectrode array was designed and fabricated by using silicon micromachining technology. The cancer cell NCI-H460 was attached on the Au microelectrode and the high impedance sensitivity at very "few...
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