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Purpose
Leber's hereditary optic neuropathy (LHON) is an inherited mitochondrial disease characterized by a painless, subacute loss of central vision with over 95% of affected patients harbouring one of three mitochondrial DNA (mtDNA) classical point mutations (m.11778G>A, m.3460G>A and m.14484T>C). The purpose of this study was to compare the age of disease onset and time interval between...
Purpose
To evaluate variations in pressurization of commercial aircraft at cruising altitude. Most aircraft are pressurized between 6,000 and 8,000 feet (ft.), depending on the type of aircraft and composite materials of the fuselage. Patients with NAION may note transient obscurations of vision in concert with low partial pressures of oxygen associated with high altitude.
Methods
Altimeters were...
Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blind, placebo-controlled design was utilized. The sample included 258 children and...
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