Lung Wa Chung

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Frontispiece: Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Tian‐Yi Wang, Xiao‐Xuan Chen, Dong‐Xing Zhu, Lung Wa Chung, more

Angewandte Chemie International Edition > 61 > 34 > n/a - n/a

Asymmetric Catalysis. An enantioselective C(sp²)−H functionalization of unprotected indoles, pyrroles, furans, thiophenes, and benzofurans by arylvinylcarbene insertion to generate heteroarene‐containing diarylmethine derivatives is reported by Ming‐Hua Xu et al. in their Research Article (e202207008).

article

Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Tian‐Yi Wang, Xiao‐Xuan Chen, Dong‐Xing Zhu, Lung Wa Chung, more

Angewandte Chemie International Edition > 61 > 34 > n/a - n/a

A rhodium(I)‐diene catalyzed highly enantioselective C(sp²)−H functionalization of simple unprotected indoles, pyrroles, and their common analogues such as furans, thiophenes, and benzofurans with arylvinyldiazoesters has been developed for the first time. This transformation features unusual site‐selectivity exclusively at the vinyl terminus of arylvinylcarbene and enables a reliable and rapid synthetic...

article

Frontispiz: Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Tian‐Yi Wang, Xiao‐Xuan Chen, Dong‐Xing Zhu, Lung Wa Chung, more

Angewandte Chemie > 134 > 34 > n/a - n/a

Asymmetrische Katalyse. Die enantioselektive C(sp²)‐H‐Funktionalisierung von ungeschützten Indolen, Pyrrolen, Furanen, Thiophenen und Benzofuranen durch Arylvinylcarben‐Insertion zur Synthese von chiralen Heteroarendiarylmethin‐Derivaten wird im Forschungsartikel von Ming‐Hua Xu et al. vorgestellt (e202207008).

article

Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Tian‐Yi Wang, Xiao‐Xuan Chen, Dong‐Xing Zhu, Lung Wa Chung, more

Angewandte Chemie > 134 > 34 > n/a - n/a

A rhodium(I)‐diene catalyzed highly enantioselective C(sp²)−H functionalization of simple unprotected indoles, pyrroles, and their common analogues such as furans, thiophenes, and benzofurans with arylvinyldiazoesters has been developed for the first time. This transformation features unusual site‐selectivity exclusively at the vinyl terminus of arylvinylcarbene and enables a reliable and rapid synthetic...

article

A Computational Study of Asymmetric Hydrogenation of 2‐Phenyl Acrylic Acids Catalyzed by a Rh(I) Catalyst with Ferrocenyl Chiral Bisphosphorus Ligand: The Role of Ion‐Pair Interaction^†

Xiangru Fan, Lini Zheng, Yuhong Yang, Xiu‐Qin Dong, more

Chinese Journal of Chemistry > 39 > 6 > 1616 - 1624

Asymmetric hydrogenation reaction is one of the most efficient synthetic methods to form useful chiral compounds for synthetic chemistry, medicinal chemistry and material chemistry. Generally, the enantioselectivity of many hydrogenation reactions is controlled by steric hindrance between the chiral ligand and substrate. Recently, Zhang group developed a highly asymmetric hydrogenation of 2‐aryl and...

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Enantioselective Hydrogenation of Tetrasubstituted α,β‐Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights

Xiaoyong Du, Ye Xiao, Yuhong Yang, Ya‐Nan Duan, more

Angewandte Chemie > 133 > 20 > 11485 - 11491

Chiral carboxylic acids are important compounds because of their prevalence in pharmaceuticals, natural products and agrochemicals. Asymmetric hydrogenation of α,β‐unsaturated carboxylic acids has been widely recognized as one of the most efficient synthetic approaches to afford such compounds. Although related asymmetric hydrogenation of di‐ and trisubstituted unsaturated acids with noble metals...

article

Enantioselective Hydrogenation of Tetrasubstituted α,β‐Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights

Xiaoyong Du, Ye Xiao, Yuhong Yang, Ya‐Nan Duan, more

Angewandte Chemie International Edition > 60 > 20 > 11384 - 11390

Chiral carboxylic acids are important compounds because of their prevalence in pharmaceuticals, natural products and agrochemicals. Asymmetric hydrogenation of α,β‐unsaturated carboxylic acids has been widely recognized as one of the most efficient synthetic approaches to afford such compounds. Although related asymmetric hydrogenation of di‐ and trisubstituted unsaturated acids with noble metals...

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Novel Molecular Doping Mechanism for n‐Doping of SnO₂ via Triphenylphosphine Oxide and Its Effect on Perovskite Solar Cells

Bao Tu, Yangfan Shao, Wei Chen, Yinghui Wu, more

Advanced Materials > 31 > 15 > n/a - n/a

Molecular doping of inorganic semiconductors is a rising topic in the field of organic/inorganic hybrid electronics. However, it is difficult to find dopant molecules which simultaneously exhibit strong reducibility and stability in ambient atmosphere, which are needed for n‐type doping of oxide semiconductors. Herein, successful n‐type doping of SnO₂ is demonstrated by a simple, air‐robust, and cost‐effective...

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Enzyme‐Inspired Chiral Secondary‐Phosphine‐Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation

Caiyou Chen, Zhefan Zhang, Shicheng Jin, Xiangru Fan, more

Angewandte Chemie International Edition > 56 > 24 > 6808 - 6812

Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary‐phosphine‐oxide) ligand (SPO‐Wudaphos) which can enter into both ion pair and H‐bond noncovalent interactions. The novel chiral SPO‐Wudaphos exhibited excellent results in the asymmetric hydrogenation of α‐methylene‐γ‐keto carboxylic acids, affording the chiral γ‐keto acids with up to over 99 % ee. A series of control...

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Enzyme‐Inspired Chiral Secondary‐Phosphine‐Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation

Caiyou Chen, Zhefan Zhang, Shicheng Jin, Xiangru Fan, more

Angewandte Chemie > 129 > 24 > 6912 - 6916

Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary‐phosphine‐oxide) ligand (SPO‐Wudaphos) which can enter into both ion pair and H‐bond noncovalent interactions. The novel chiral SPO‐Wudaphos exhibited excellent results in the asymmetric hydrogenation of α‐methylene‐γ‐keto carboxylic acids, affording the chiral γ‐keto acids with up to over 99 % ee. A series of control...

article

Guest‐Induced Folding and Self‐Assembly of Conformationally Adaptive Macrocycles into Nanosheets and Nanotubes

Liu‐Pan Yang, Fei Jia, Qing‐Hai Zhou, Fangfang Pan, more

Chemistry – A European Journal > 23 > 7 > 1516 - 1520

A conformationally adaptive macrocycle is presented, namely zorb[4]arene, which exists in multiple conformations in the uncomplexed state. The binding cavity of zorb[4]arene is concealed, either due to a collapsed conformation or by self‐inclusion. The zorb[4]arene with long alkyl chains manifests itself with surprisingly low melting point and thus exist as an oil at room temperature. Binding of a...

article

Highly Regio‐ and Stereoselective Hydrosilylation of Internal Thioalkynes under Mild Conditions

Shengtao Ding, Li‐Juan Song, Yong Wang, Xinhao Zhang, more

Angewandte Chemie > 127 > 19 > 5724 - 5727

A general and mild hydrosilylation of thioalkynes is described. With the cationic catalyst [Cp*Ru(MeCN)₃]⁺ and the bulky silane (TMSO)₃SiH, a range of thioalkynes underwent smooth hydrosilylation at room temperature with excellent α regioselectivity and syn stereoselectivity. DFT calculations provided important insight into the mechanism, particularly the unusual syn selectivity with the [Cp*Ru(MeCN)...

article

Highly Regio‐ and Stereoselective Hydrosilylation of Internal Thioalkynes under Mild Conditions

Shengtao Ding, Li‐Juan Song, Yong Wang, Xinhao Zhang, more

Angewandte Chemie International Edition > 54 > 19 > 5632 - 5635

A general and mild hydrosilylation of thioalkynes is described. With the cationic catalyst [Cp*Ru(MeCN)₃]⁺ and the bulky silane (TMSO)₃SiH, a range of thioalkynes underwent smooth hydrosilylation at room temperature with excellent α regioselectivity and syn stereoselectivity. DFT calculations provided important insight into the mechanism, particularly the unusual syn selectivity with the [Cp*Ru(MeCN)...

article

Dearomative Indole [5+2] Cycloaddition Reactions: Stereoselective Synthesis of Highly Functionalized Cyclohepta[b]indoles

Guangjian Mei, Hao Yuan, Yueqing Gu, Wei Chen, more

Angewandte Chemie > 126 > 41 > 11231 - 11235

The first dearomative indole [5+2] cycloaddition reaction with an oxidopyrylium ylide resulted in efficient and diastereoselective construction of some highly functionalized and synthetically challenging oxacyclohepta[b]indoles. The protocol proceeds under very mild reaction conditions, thus enabling high functional‐group tolerance and unique endo selectivity.

article

Dearomative Indole [5+2] Cycloaddition Reactions: Stereoselective Synthesis of Highly Functionalized Cyclohepta[b]indoles

Guangjian Mei, Hao Yuan, Yueqing Gu, Wei Chen, more

Angewandte Chemie International Edition > 53 > 41 > 11051 - 11055

The first dearomative indole [5+2] cycloaddition reaction with an oxidopyrylium ylide resulted in efficient and diastereoselective construction of some highly functionalized and synthetically challenging oxacyclohepta[b]indoles. The protocol proceeds under very mild reaction conditions, thus enabling high functional‐group tolerance and unique endo selectivity.

article

Mechanistic Studies on the Reversible Hydrogenation of Carbon Dioxide Catalyzed by an Ir-PNP Complex

Ryo Tanaka, Makoto Yamashita, Lung Wa Chung, Keiji Morokuma, more

Organometallics > 2011 > 30 > 24 > 6742 - 6750

article

Comparative Reactivity of Ferric-Superoxo and Ferryl-Oxo Species in Heme and Non-Heme Complexes

Lung Wa Chung, Xin Li, Hajime Hirao, Keiji Morokuma

Journal of the American Chemical Society > 2011 > 133 > 50 > 20076 - 20079

article

Zinc–Homocysteine binding in cobalamin‐dependent methionine synthase and its role in the substrate activation: DFT, ONIOM, and QM/MM molecular dynamics studies

Safwat Abdel‐Azeim, Xin Li, Lung Wa Chung, Keiji Morokuma

Journal of Computational Chemistry > 32 > 15 > 3154 - 3167

Cobalamin‐dependent methionine synthase (MetH) is an important metalloenzyme responsible for the biosynthesis of methionine. It catalyzes methyl transfer from N⁵‐methyl‐tetrahydrofolate to homocysteine (Hcy) by using a zinc ion to activate the Hcy substrate. Density functional theory (B3LYP) calculations on the active‐site model in gas phase and in a polarized continuum model were performed to study...

article

Photodynamics of All- trans Retinal Protonated Schiff Base in Bacteriorhodopsin and Methanol Solution

Xin Li, Lung Wa Chung, Keiji Morokuma

Journal of Chemical Theory and Computation > 2011 > 7 > 9 > 2694 - 2698

article

Pd-Catalyzed Copolymerization of Methyl Acrylate with Carbon Monoxide: Structures, Properties and Mechanistic Aspects toward Ligand Design

Akifumi Nakamura, Kagehiro Munakata, Shingo Ito, Takuya Kochi, more

Journal of the American Chemical Society > 2011 > 133 > 17 > 6761 - 6779

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Search results for: Lung Wa Chung

Frontispiece: Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Frontispiz: Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

Rhodium(I) Carbene‐Promoted Enantioselective C−H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights

A Computational Study of Asymmetric Hydrogenation of 2‐Phenyl Acrylic Acids Catalyzed by a Rh(I) Catalyst with Ferrocenyl Chiral Bisphosphorus Ligand: The Role of Ion‐Pair Interaction^†

Enantioselective Hydrogenation of Tetrasubstituted α,β‐Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights

Enantioselective Hydrogenation of Tetrasubstituted α,β‐Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights

Novel Molecular Doping Mechanism for n‐Doping of SnO₂ via Triphenylphosphine Oxide and Its Effect on Perovskite Solar Cells

Enzyme‐Inspired Chiral Secondary‐Phosphine‐Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation

Enzyme‐Inspired Chiral Secondary‐Phosphine‐Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation

Guest‐Induced Folding and Self‐Assembly of Conformationally Adaptive Macrocycles into Nanosheets and Nanotubes

Highly Regio‐ and Stereoselective Hydrosilylation of Internal Thioalkynes under Mild Conditions

Highly Regio‐ and Stereoselective Hydrosilylation of Internal Thioalkynes under Mild Conditions

Dearomative Indole [5+2] Cycloaddition Reactions: Stereoselective Synthesis of Highly Functionalized Cyclohepta[b]indoles

Dearomative Indole [5+2] Cycloaddition Reactions: Stereoselective Synthesis of Highly Functionalized Cyclohepta[b]indoles

Mechanistic Studies on the Reversible Hydrogenation of Carbon Dioxide Catalyzed by an Ir-PNP Complex

Comparative Reactivity of Ferric-Superoxo and Ferryl-Oxo Species in Heme and Non-Heme Complexes

Zinc–Homocysteine binding in cobalamin‐dependent methionine synthase and its role in the substrate activation: DFT, ONIOM, and QM/MM molecular dynamics studies

Photodynamics of All- trans Retinal Protonated Schiff Base in Bacteriorhodopsin and Methanol Solution

Pd-Catalyzed Copolymerization of Methyl Acrylate with Carbon Monoxide: Structures, Properties and Mechanistic Aspects toward Ligand Design

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