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Interferonα (IFNα) induces cell cycle arrest and triggers apoptosis and chemosensitivity. But the mechanism of IFNα in regulating chemosensitivity has not been fully understood. To study whether IFNα affected chemosensitivity of osteosarcoma cells, we treated p53-wild U2OS cells and p53-mutant MG63 cells with IFNα and etoposide, alone or in combination, and then examined growth inhibition, cell cycle...
p33 ING1b induces cell cycle arrest and stimulates DNA repair, apoptosis and chemosensitivity. The magnitude of some p33 ING1b effects may be due to activation of the tumor suppressor p53. To investigate if the p33 ING1b protein affected chemosensitivity of osteosarcoma cells, we overexpressed p33 ING1b in p53+/+ U2OS cells or in p53-mutant MG63 cells, and then assessed...
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