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Interferonα (IFNα) induces cell cycle arrest and triggers apoptosis and chemosensitivity. But the mechanism of IFNα in regulating chemosensitivity has not been fully understood. To study whether IFNα affected chemosensitivity of osteosarcoma cells, we treated p53-wild U2OS cells and p53-mutant MG63 cells with IFNα and etoposide, alone or in combination, and then examined growth inhibition, cell cycle...