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Background
Average paternal age in the United States has increased substantially in the last few decades. Children of advanced age fathers have a higher incidence of early onset cancer and neuropsychiatric disease.
Objectives
To quantify the number of population adjusted cases of early‐onset cancer and neuropsychiatric disease in children attributable to increasing paternal age in the United States...
Background
Several studies have linked vasectomy with the risk of prostate cancer; however, this association has been attributed to selection bias. Since vasectomy is a common and effective form of contraception, these implications are significant. Therefore, we sought to test this association in a large observational cohort.
Objective
To evaluate the potential association between prior vasectomy...
Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio‐economic status. We aimed to investigate whether the association between semen quality and subsequent risk of hospitalization could be explained by differences in occupation, education,...
This study aims to evaluate whether cancer treatments differ in infertile men compared to men who have undergone vasectomy and age‐matched controls. We analyzed subjects from the Truven Health MarketScan Claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups included vasectomized men and an age‐matched cohort who were not infertile...
Aberrations in reproductive fitness may be a harbinger of medical diseases in men. Existing data suggest that female infertility is associated with autoimmune disorders; however, this has not been examined in men. As immune surveillance and hormonal factors can impact male fertility and autoimmunity, we sought to determine the association between male infertility and incident autoimmune disorders...
Studies have suggested an association between varicocele, hypogonadism, and elevated oxidative stress markers, but no other health risks have been associated with varicoceles. We sought to determine the association between varicocele and incident medical comorbidities. Using the Truven Health MarketScan® claims database from 2001 to 2009, we identified...
Our objective was to investigate the relationship between male underwear‐type worn during daytime/bedtime and male fecundity as measured by semen quality and time‐to‐pregnancy. We used data from a prospective preconception cohort conducted in 16 counties in Michigan and Texas, USA. 501 couples were enrolled and followed for 12 months of trying, which facilitated capture of time‐to‐pregnancy (in cycles),...
Controversy exists regarding stability of semen quality over time with papers reporting decrease, increase or stable parameters in heterogeneous populations. The current study examined semen parameters of young adult men from 2003 to 2013 at an urban U.S. sperm bank. Semen parameters were analyzed before and after cryopreservation for a total of 9425 specimens from 489 individuals. Demographic information...
In humans, recent studies have correlated anogenital distance (AGD) in adult men to intrinsic testicular function. Although rodent studies suggest that AGD is determined in utero and remains constant in adult life, it is not certain if AGD remains constant across a man's adult life. We sought to determine if adult male AGD varies based on age. A cross‐sectional study of men being evaluated at a men's...
A novel method is presented whereby the neutron-induced degradation characteristics of semiconductor components can be predicted, and total assurance of operation can be attained even under severe radiation environments. The method, involving irradiation-annealing cycles is shown to be economical and reliable in the wafer stage, and feasible for packaged off the shelf hardened components. Radiation...
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