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Pomegranate (POM) juice may benefit the erectile process, but the scientific evidence is lacking. This study evaluates the molecular characterisation and confirmation of POM's action on human corpus cavernosum (HCC) obtained from patients (n = 16) undergoing penile prosthesis implantation. After phenylephrine contraction, the relaxant effects of POM with various inhibitors in the presence and absence...
Angioplasty followed by stent placement, bare or drug-eluting, proved to be a major step forward in the treatment of coronary and carotid artery disease. It was soon recognized that patients undergoing these procedures presented with restenosis within 6 months. The cause of these failures was the development of intimal hyperplasia. Aspirin, acetylsalicylic acid, soon became a focus of therapeutic...
We compared the activity of a new phosphodiesterase‐5 inhibitor (PDE5i) avanafil with sildenafil and tadalafil in human and rat corpus cavernosum (CC) tissues. The effect of avanafil with several inhibitors and electrical field stimulation (EFS) was evaluated on CC after pre‐contraction with phenylephrine. With the PDE5i, sildenafil and tadalafil, concentration–response curves were obtained and cyclic...
Peyronie's disease (PD) is a localized connective tissue disorder that involves the tunica albuginea (TA) of the penis. While surgical correction remains the gold standard, the search for an effective and less invasive therapy continues. The objective of this study was to evaluate the effects of intratunical injection of adipose tissue–derived stem cells (ADSCs) for the prevention and treatment of...
Champion, H. C., J. A. Santiago, M. A. Czapla, T. J. Bivalacqua, C. Ilgenfritz and P. J. Kadowitz.Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat.Peptides 18(9) 1357-1364, 1997.-Responses to T-kinin and bradykinin were compared in the mesenteric vascular bed of the cat. Under constant-flow conditions, injection of T-kinin and bradykinin into the perfusion...
Responses to a newly synthesized human adrenomedullin (hADM) analog, hADM(16-31), were investigated in the rat and cat. Unlike the full-sequence peptide, which has potent hypotensive activity, hADM(16-31) had pressor activity in the rat but not in the cat. Injection of hADM(16-31) in doses of 10-300 nmol/kg IV induced dose-dependent increases in systemic arterial pressure in the rat, and the peptide...
Czapla, M. A., H. C. Champion and P. J. Kadowitz.Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat.Peptides 18(8) 1197-1200, 1997.-Nociceptin, the endogenous ligand for the ORL 1 receptor, has been shown to decrease systemic arterial and hindquarters perfusion pressures in the rat. The present study was undertaken...
Responses to proadrenomedullin NH 2 -terminal 20 peptide (PAMP) were investigated in the systemic and hindquarters vascular bed of the rat. Intravenous injections of PAMP and adrenomedullin (ADM) produced dose-related decreases in systemic arterial and hindquarters perfusion pressure, which were not altered by α-receptor or adrenergic nerve terminal blocking agents. PAMP was 100-fold less...
Responses to proadrenomedullin NH 2 -terminal 20 peptide (hPAMP), a truncated analogue [hPAMP (12-20)], and adrenomedullin (hADM) were investigated in the mesenteric vascular bed of the cat. Under constant-flow conditions, injections of hPAMP, hPAMP (12-20), and hADM caused dose-related decreases in mesenteric perfusion pressure. hADM was 100-fold more potent than hPAMP, and 1000-fold more...
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