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Objective
Migraine is three times more common in women. CGRP plays a critical role in migraine pathology and causes female‐specific behavioral responses upon meningeal application. These effects are likely mediated through interactions of CGRP with signaling systems specific to females. Prolactin (PRL) levels have been correlated with migraine attacks. Here, we explore a potential interaction between...
Sensory neurones exhibit sex‐dependent responsiveness to prolactin (PRL). This could contribute to sexual dimorphism in pathological pain conditions. The present study aimed to determine the mechanisms underlying sex‐dependent PRL sensitivity in sensory neurones. A quantitative reverse transcriptase‐polymerase chain reaction shows that prolactin receptor (Prlr) long and short isoform mRNAs are expressed...
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