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Calcineurin inhibitors (CNI) are powerful immunomodulatory agents that produce marked renal dysfunction due in part to endothelin‐1‐mediated reductions in renal blood flow. Ligand‐stimulated Gq protein signaling promotes the contraction of smooth muscle cells via phospholipase Cβ‐mediated stimulation of cytosolic calcium release. RGS4 is a GTPase activating protein that promotes the deactivation of...