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This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype–guided antiplatelet therapy after percutaneous coronary intervention (PCI).CYP2C19 loss-of-function alleles impair clopidogrel effectiveness after PCI.After clinical genotyping, each institution recommended alternative antiplatelet therapy (prasugrel, ticagrelor) in PCI patients with a...
Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to a number of non‐trivial practical barriers. We implemented a Personalized Anti‐platelet Pharmacogenetics Program (PAP3) for cardiac catheterization patients at the University of Maryland Medical Center and the Baltimore Veterans Administration Medical Center Patients' are offered...
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