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Systemic mastocytosis (SM) corresponds to a rare and heterogeneous spectrum of diseases characterized by the accumulation of atypical mast cells (MCs). Advanced mastocytosis (Adv‐SM) is associated with poor survival; in contrast, patients with non‐advanced SM (non‐Adv‐SM) usually have a normal life expectancy but may experience poor quality of life. Despite recent therapeutic progress including tyrosine...