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Ein systematischer Ansatz für die Entwicklung oral verfügbarer wie auch biologisch aktiver, cyclischer, N‐methylierter Hexapeptide als hoch affine Liganden für das Integrin αvβ3 beruht auf zwei Konzepten: a) Screening systematisch entwickelter Peptidbibliotheken mit räumlicher Diversität und b) Maskierung der Peptidladung mithilfe lipophiler Schutzgruppen. Die Schlüsselschritte dieser Methode sind...
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