Search results for: Lucy Morgan

Items from 1 to 17 out of 17 results

article

The first Australian experience with ward‐based continuous positive airway pressure for COVID‐19 respiratory failure: a retrospective cohort study

Benjamin Gerhardy, Monica Comsa, Ali Tahir, Dalton Lynch, more

Internal Medicine Journal > 52 > 11 > 1986 - 1990

We present the first Australian cohort of patients with COVID‐19 respiratory failure managed with escalating respiratory support including continuous positive airway pressure (CPAP) on a standard medical ward at a tertiary Sydney hospital during the 2021 COVID‐19 Delta variant outbreak. We demonstrate an equivalent mortality to CPAP delivered in intensive care unit and outline our ward structure and...

article

Fissure adjacent partial lobe atelectasis in primary ciliary dyskinesia

Loraine Fabri, Shivanthan Shanthikumar, Katelyn Tadd, Lucy Morgan, more

Journal of Paediatrics and Child Health > 58 > 4 > 683 - 686

Aim Establishing the underlying cause in a child with chronic suppurative lung disease (CSLD) allows for targeted treatment and screening for associated complications. One cause of CSLD is primary ciliary dyskinesia (PCD). Testing for PCD requires specialist expertise which is not widely available. Computed tomography (CT) scans are commonly performed when assessing CSLD. Identifying PCD‐specific...

article

Nurse‐led integration of palliative care for chronic obstructive pulmonary disease: An integrative literature review

Linda Ora, Judy Mannix, Lucy Morgan, Lesley Wilkes

Journal of Clinical Nursing > 28 > 21-22 > 3725 - 3733

Aims and objectives To uncover what is known about nurse‐led models or interventions that have integrated palliative care into the care of patients with chronic obstructive pulmonary disease. Background Chronic obstructive pulmonary disease is a highly symptomatic, incurable disease characterised by chronic symptoms that without appropriate palliation can lead to unnecessary suffering for patients...

article

Prevalence and course of disease after lung resection in primary ciliary dyskinesia: a cohort & nested case-control study

Panayiotis Kouis, Myrofora Goutaki, Florian S. Halbeisen, Ifigeneia Gioti, more

Respiratory Research > 2019 > 20 > 1 > 1-12

Background Lung resection is a controversial and understudied therapeutic modality in Primary Ciliary Dyskinesia (PCD). We assessed the prevalence of lung resection in PCD across countries and compared disease course in lobectomised and non-lobectomised patients. Methods In the international iPCD cohort, we identified lobectomised and non-lobectomised age and sex-matched PCD patients and compared...

article

For whom the egg thaws: insights from an analysis of 10 years of frozen egg thaw data from two UK clinics, 2008–2017

Zeynep B. Gürtin, Lucy Morgan, David O’Rourke, Jinjun Wang, more

Journal of Assisted Reproduction and Genetics > 2019 > 36 > 6 > 1069-1080

Purpose To better understand the characteristics of patients who returned to thaw their frozen eggs to attempt conception and their outcomes. Methods A retrospective analysis of clinical records for all own egg thaw patients in two UK fertility clinics across 10 years, 2008–2017. Results There were 129 patients who returned to thaw their eggs, of which 46 had originally frozen their eggs for social...

article

CF derived scoring systems do not fully describe the range of structural changes seen on CT scans in PCD

Katelyn Tadd, Lucy Morgan, Tim Rosenow, André Schultz, more

Pediatric Pulmonology > 54 > 4 > 471 - 477

Background Structural lung changes seen on computed tomography (CT) scans in Cystic Fibrosis (CF) and Primary Ciliary Dyskinesia (PCD) are currently described using scoring systems derived from CF populations. This practise assumes lung damage in the two conditions is identical, potentially resulting in a failure to identify PCD‐specific changes. Our study addresses this assumption. Methods A total...

article

Bronchiectasis in PCD looks different to CF on CT scan

Philip Robinson, Lucy Morgan

Multidisciplinary Respiratory Medicine > 2018 > 13 > 1 > 5-8

Background The contemporary diagnosis of bronchiectasis requires CT scanning to describe specific structural lung changes. Scoring systems have been designed and validated in some specific causes of bronchiectasis to allow investigators to correlate CT changes with other indices of disease severity, to describe changes over time, with exacerbation and in response to treatment. Several scoring systems...

article

Application of RPMI 2650 nasal cell model to a 3D printed apparatus for the testing of drug deposition and permeation of nasal products

Michele Pozzoli, Hui Xin Ong, Lucy Morgan, Maria Sukkar, more

European Journal of Pharmaceutics and Biopharmaceutics > 2016 > 107 > C > 223-233

The aim of this study was to incorporate an optimized RPMI2650 nasal cell model into a 3D printed model of the nose to test deposition and permeation of drugs intended for use in the nose. The nasal cell model was optimized for barrier properties in terms of permeation marker and mucus production. RT-qPCR was used to determine the xenobiotic transporter gene expression of RPMI 2650 cells in comparison...

article

Syndrome diagnosis with single‐nucleotide polymorphism (SNP) microarray

Matthew Edwards, Sally Brescianini, Catherine Allgood, Michael Freelander, more

Journal of Paediatrics and Child Health > 52 > 1 > 85 - 89

chapter

Beating cilia identification in fluorescence microscope images for accurate CBF measurement

Fan Zhang, Weidong Cai, Yang Song, Paul Young, more

2015 IEEE International Conference on Image Processing (ICIP) > 4496 - 4500

2015 IEEE International Conference on Image Processing (ICIP)

Ciliary beating frequency (CBF) is a regulated quantitative measurement to describe ciliary beating properties. It is widely used for diagnosis of defective mucociliary clearance diseases. Image-based methods can be effective for CBF estimation but also affected by the moving objects such as ciliated cells and debris. In this work, we propose a CBF estimation method by removing these unfavorable objects,...

article

Primary ciliary dyskinesia: Overlooked and undertreated in children

Patrick Hosie, Dominic A Fitzgerald, Adam Jaffe, Catherine S Birman, more

Journal of Paediatrics and Child Health > 50 > 12 > 952 - 958

Primary ciliary dyskinesia (PCD) is a multi‐organ disorder associated with chronic oto‐sino‐pulmonary disease, neonatal respiratory distress, situs abnormalities and reduced fertility. Repeated respiratory tract infections leads to the almost universal development of bronchiectasis. These clinical manifestations are a consequence of poorly functioning motile cilia. However, confirming the diagnosis...

chapter

Image-based ciliary beating frequency estimation for therapeutic assessment on defective mucociliary clearance diseases

Fan Zhang, Weidong Cai, Yang Song, Paul Young, more

2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) > 193 - 196

2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI 2014)

Defective mucociliary clearance is inevitably seen in the chronic lung diseases and contributes substantially to their pathologies, and increasing the ciliary motility with external stimuli is considered to be efficient to relieve it. Ciliary Beating Frequency (CBF) is a regulated measurement to evaluate the drugs by comparing their effects on the motility of cilia. Therefore, CBF estimation is crucial...

article

Combined Inhaled Salbutamol and Mannitol Therapy for Mucus Hyper-secretion in Pulmonary Diseases

Hui Xin Ong, Daniela Traini, Giulia Ballerin, Lucy Morgan, more

The AAPS Journal > 2014 > 16 > 2 > 269-280

This study focuses on the co-engineering of salbutamol sulphate (SS), a common bronchodilator, and mannitol (MA), a mucolytic, as a potential combination therapy for mucus hypersecretion. This combination was chosen to have a synergic effect on the airways: the SS will act on the β₂-receptor for relaxation of smooth muscle and enhancement of ciliary beat frequency, whilst mannitol will improve the...

article

RPGR mutations might cause reduced orientation of respiratory cilia

Zuzanna Bukowy‐Bieryłło, Ewa Ziętkiewicz, Niki Tomas Loges, Mariana Wittmer, more

Pediatric Pulmonology > 48 > 4 > 352 - 363

RPGR gene encodes retinitis pigmentosa guanosine triphosphatase regulator protein, mutations of which cause 70% of the X‐linked retinitis pigmentosa (XLRP) cases. Rarely, RPGR mutations can also cause primary ciliary dyskinesia (PCD), a multisystem disorder characterized by recurrent respiratory tract infections, sinusitis, bronchiectasis, and male subfertility. Two patients with PCD_RP and their...

article

Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected, primary human airway smooth muscle

David Van Ly, Monique De Pedro, Peter James, Lucy Morgan, more

Respiratory Research > 2013 > 14 > 1 > 1-11

Background Virus-induced exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a significant health burden and occur even in those receiving the best current therapies. Rhinovirus (RV) infections are responsible for half of all COPD exacerbations. The mechanism by which exacerbations occur remains undefined, however it is likely to be due to virus-induced inflammation. Given that phophodiesterase...

article

(13) Management of Otitis Media With Effusion in Children With Primary Ciliary Dyskinesia

Raewyn Campbell, Catherine Birman, Lucy Morgan

Otolaryngology - Head and Neck Surgery > 2010 > 143 > 5 Supplement 3 > S46-S47

article

Hypertrophic pulmonary osteoarthropathy without clubbing of the digits

Stephen Clarke, Leslie Barnsley, Matthew Peters, Lucy Morgan, more

Skeletal Radiology > 2001 > 30 > 11 > 652-655

Abstract. Hypertrophic osteoarthropathy (HOA) typically occurs concurrently with clubbing of the digits, with isolated HOA being reported only rarely. We report two patients with intra-thoracic malignancy in whom HOA, demonstrated on bone scintigraphy, developed in the absence of clubbing. We also report the novel observation of involvement of the metatarsal and metacarpal bones by HOA.

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