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It was shown that serpinb1a is expressed during differentiation of PC12 cells induced by nerve growth factor (NGF). Here, we found that overexpression of serpinb1a in PC12 cells weakly but significantly increases PC12 survival during staurosporine-induced apoptosis. Immunoprecipitation of serpinb1a after its overexpression in PC12 showed that this protein interacts with active caspase-3 in both resting...
The aim of our study was to investigate the effect of lentivirus-induced Wnt3a overexpression in the dentate gyrus of the hippocampus on the intensity of neurogenesis in this neurogenic zone of adult rats. Virus transduction resulting in local overproduction of Wnt3a was accompanied by a significant decrease in the density of doublecortin-positive cells in the transfected area. This may reflect the...
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