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JMJD3, a Jumonji C family histone demethylase, plays an important role in the regulation of inflammation induced by the transcription factor nuclear factor-kappa B (NF-κB) in response to various stimuli. JMJD3 is a histone-3 lysine-27 trimethylation (H3K27me3) demethylase, a histone mark associated with transcriptional repression and activation of a diverse set of genes. The present study assessed...
Anthrax lethal toxin (LeTx; a combination of protective antigen and lethal factor) is secreted by the vegetative cells of Bacillus anthracis and is cytotoxic for certain macrophage cell lines. First-time exposure of murine macrophage cells (RAW 264.7) to lethal toxin (LeTx) (0.1+0.1 mg/mL) caused extensive cell death with a survival rate of approximately 40%, but upon secondary exposure to LeTx and...
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