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The role of biological sex in short-term and long-term outcome after traumatic brain injury (TBI) remains controversial. The observation that exogenous female sex steroids (progesterone and estrogen) reduce brain injury coupled with a small number of clinical studies showing smaller injury in women suggest that sex steroids may play a role in outcome from TBI. We used the controlled cortical impact...
The time course and pattern of development of hippocampal α7 nicotinic acetylcholine receptors is discernibly different in C3H and DBA/2 mice. In C3H mice, the α7 receptor is initially expressed on embryonic day 13, exhibits an increase in density in area CA1 perinatally and is characterized by a dense, diffuse band of α-bungarotoxin binding at the CA3/CA1 border in the adult. In contrast, the α7...
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