Search results for: Nikolaj Gadegaard

Items from 1 to 20 out of 60 results

article

Scalable, Transparent, and Micro: 3D‐Printed Rapid Tooling for Injection Molded Microfluidics

Pedro Duarte Menezes, Alysha Hunter, Thomas Dickson, Soren Hecht, more

Advanced Engineering Materials > 26 > 20 > n/a - n/a

The fast‐growing 3D printing industry is improving its hardware at an accelerated pace. This includes higher‐resolution printing combined with a wider range of photosensitive resins. The parallel development of rapid tooling (RT) for injection molding enables upscaling 3D‐printed designs. Within microfluidics, where prototyping and scalability are key, the development of 3D‐printed RT for injection...

article

3D‐Printed Polyetheretherketone Smart Polymer Nanocomposite Scaffolds: Mechanical, Self‐Sensing, and Biological Attributes

Johannes Schneider, Srijani Basak, Yanan Hou, Joseph H. Koo, more

Advanced Engineering Materials > 26 > 4 > n/a - n/a

Nanocomposite Scaffolds In article number 2301659, S. Kumar and co‐workers investigate the mechanical, self‐sensing, and biological performance of advanced 3D‐printed PEEK scaffolds reinforced with carbon nanotubes and graphene nanoplatelets for bone tissue engineering applications. The findings underscore the impressive mechanical strength, piezoresistive properties, and excellent cytocompatibility...

article

3D‐Printed Polyetheretherketone Smart Polymer Nanocomposite Scaffolds: Mechanical, Self‐Sensing, and Biological Attributes

Johannes Schneider, Srijani Basak, Yanan Hou, Joseph H. Koo, more

Advanced Engineering Materials > 26 > 4 > n/a - n/a

This study demonstrates the mechanical, self‐sensing, and biological characteristics of carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs)‐engineered 3D‐printed polyetheretherketone (PEEK) composite scaffolds, utilizing custom‐made feedstocks. Microstructural analysis and macroscale testing reveal that the PEEK/CNT scaffolds with 6 wt% CNT content and 46% relative density achieve a gauge factor...

article

3D Printing and Rapid Replication of Advanced Numerically Generated Rough Surface Topographies in Numerous Polymers

Jack Perris, Charchit Kumar, Yang Xu, Manlio Tassieri, more

Advanced Engineering Materials > 25 > 1 > n/a - n/a

An approach to rapidly produce high‐quality polymer surface topographies from numerically generated surfaces is presented. The approach uses an advanced surface generation tool to flexibly design surfaces with user‐defined topography characteristics over a large range of surface roughness. Roughness instances with root mean square roughness 25, 50, and 100 μm are studied. 3D printing is used to create...

article

Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell‐derived cardiomyocytes

Eline Huethorst, Peter Mortensen, Radostin D. Simitev, Hao Gao, more

The Journal of Physiology > 600 > 3 > 483 - 507

Abstract Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) in monolayers interact mechanically via cell–cell and cell–substrate adhesion. Spatiotemporal features of contraction were analysed in hiPSC‐CM monolayers (1) attached to glass or plastic (Young's modulus (E) >1 GPa), (2) detached (substrate‐free) and (3) attached to a flexible collagen hydrogel (E = 22 kPa). The effects...

article

3D Printed Tooling for Injection Molded Microfluidics

Neil Convery, Iliyana Samardzhieva, John Moir Stormonth‐Darling, Sean Harrison, more

Macromolecular Materials and Engineering > 306 > 11 > n/a - n/a

Microfluidics have been used for several decades to conduct a wide range of research in chemistry and the life sciences. The reduced dimensions of these devices give them advantages over classical analysis techniques such as increased sensitivity, shorter analysis times, and lower reagent consumption. However, current manufacturing processes for microfluidic chips either limit them to materials with...

article

Flexible Inserts for Injection Molding of Complex Micro‐Structured Polymer Components

Alex Hamilton, Jack Perris, Neil Convery, Daniel M. Mulvihill, more

Macromolecular Materials and Engineering > 306 > 9 > n/a - n/a

Mass production of microfluidic devices commonly relies on injection molding. Injection molding requires a master surface made using micro or nanofabrication. Conventionally, electroplating from a silicon master is used for mold insert production, but this is expensive and cannot be used with masters produced via the Bosch process as interlocking of the scalloping between polymer and metal insert...

article

Modelling human liver microphysiology on a chip through a finite element based design approach

Pedro Duarte Menezes, Nikolaj Gadegaard, Renato M. Natal Jorge, Sónia I. S. Pinto

International Journal for Numerical Methods in Biomedical Engineering > 37 > 5 > n/a - n/a

Organ‐on‐a‐chip (OoaC) are microfluidic devices capable of growing living tissue and replicate the intricate microenvironments of human organs in vitro, being heralded as having the potential to revolutionize biological research and healthcare by providing unprecedented control over fluid flow, relevant tissue to volume ratio, compatibility with high‐resolution content screening and a reduced footprint...

article

PC234 Promoting Endothelial Cell Adhesion by Modulation of Prosthetic Surface Topography at the Nano-Scale

Debra S.T. Chong, Umber Cheema, Nikolaj Gadegaard, Matthew Dalby, more

Journal of Vascular Surgery > 2017 > 65 > 6(S) > 202S

article

Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring

Sanjiv Sharma, Anwer Saeed, Christopher Johnson, Nikolaj Gadegaard, more

Sensing and Bio-Sensing Research > 2017 > 13 > C > 104-108

The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems...

article

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

Louisa C.Y. Lee, Nikolaj Gadegaard, María C. de Andrés, Lesley-Anne Turner, more

Biomaterials > 2017 > 116 > C > 10-20

In culture isolated bone marrow mesenchymal stem cells (more precisely termed skeletal stem cells, SSCs) spontaneously differentiate into fibroblasts, preventing the growth of large numbers of multipotent SSCs for use in regenerative medicine. However, the mechanisms that regulate the expansion of SSCs, while maintaining multipotency and preventing fibroblastic differentiation are poorly understood...

article

Fabrication of mesoscale topographical gradients in bulk titanium and their use in injection moulding

Andrew Connell, Paul M. Reynolds, Anwer Saeed, Nikolaj Gadegaard

Microelectronic Engineering > 2016 > 164 > C > 36-42

Fabrication methods for titanium substrates exhibiting continuous micro and nano scale arrays, with increasing feature heights over the length of the array are reported. The resultant feature heights spanned 0–2μm. Patterned gradient arrays of circular features with diameters of: 500nm, 1μm and 2μm, spaced by twice the diameter were manufactured by the process using specially prepared titanium substrates...

article

Characterisation of CorGlaes^® Pure 107 fibres for biomedical applications

Ross Colquhoun, Nikolaj Gadegaard, David M. Healy, K. Elizabeth Tanner

Journal of Materials Science: Materials in Medicine > 2016 > 27 > 10 > 1-16

A degradable ultraphosphate (55 mol % P₂O₅) quinternary phosphate glass composition has been characterised in terms of its chemical, mechanical and degradation properties both as a bulk material and after drawing into fibres. This glass formulation displayed a large processing window simplifying fibre drawing. The fibres displayed stiffness and strength of 65.5 ± 20.8 GPa and 426±143 MPa. While amorphous...

article

Nanostructures: Enhanced Differentiation of Human Embryonic Stem Cells Toward Definitive Endoderm on Ultrahigh Aspect Ratio Nanopillars (Adv. Funct. Mater. 6/2016)

Camilla Holzmann Rasmussen, Paul M. Reynolds, Dorthe Roenn Petersen, Mattias Hansson, more

Advanced Functional Materials > 26 > 6 > 814 - 814

N. Gadegaard and co‐workers report on page 815 a nanofabricated thermoplastic substrate with ultra‐high aspect ratio nanopillars. This substrate, formed via injection molding, is used to enhance the differentiation of human embryonic stem cells. The nanostructured surface results in a softer substrate, which mimics the natural extracellular environment.

article

Enhanced Differentiation of Human Embryonic Stem Cells Toward Definitive Endoderm on Ultrahigh Aspect Ratio Nanopillars

Camilla Holzmann Rasmussen, Paul M. Reynolds, Dorthe Roenn Petersen, Mattias Hansson, more

Advanced Functional Materials > 26 > 6 > 815 - 823

Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes. The directed differentiation of human embryonic stem cells relies mainly on soluble factors. Although, some studies have highlighted that the properties of the physical environment, such as substrate stiffness, affect cellular...

article

Mechanical compatibility of sol–gel annealing with titanium for orthopaedic prostheses

Andrew I. M. Greer, Teoh S. Lim, Alistair S. Brydone, Nikolaj Gadegaard

Journal of Materials Science: Materials in Medicine > 2016 > 27 > 1 > 1-6

Sol–gel processing is an attractive method for large-scale surface coating due to its facile and inexpensive preparation, even with the inclusion of precision nanotopographies. These are desirable traits for metal orthopaedic prostheses where ceramic coatings are known to be osteoinductive and the effects may be amplified through nanotexturing. However there are a few concerns associated with the...

article

Step-and-Repeat Nanoimprint-, Photo- and Laser Lithography from One Customised CNC Machine

Andrew Im Greer, Benoit Della-Rosa, Ali Z. Khokhar, Nikolaj Gadegaard

Nanoscale Research Letters > 2016 > 11 > 1 > 1-9

The conversion of a computer numerical control machine into a nanoimprint step-and-repeat tool with additional laser- and photolithography capacity is documented here. All three processes, each demonstrated on a variety of photoresists, are performed successfully and analysed so as to enable the reader to relate their known lithography process(es) to the findings. Using the converted tool, 1 cm² of...

article

Disposable Plasmonics: Plastic Templated Plasmonic Metamaterials with Tunable Chirality

Affar S. Karimullah, Calum Jack, Ryan Tullius, Vincent M. Rotello, more

Advanced Materials > 27 > 37 > 5610 - 5616

Development of low‐cost disposable plasmonic substrates is vital for the applicability of plasmonic sensing. Such devices can be made using injection‐molded templates to create plasmonic films. The elements of these plasmonic films are hybrid nanostructures composed of inverse and solid structures. Tuning the modal coupling between the two allows optimization of the optical properties for nanophotonic...

article

Strategies for High Quality Injection Moulding of Polymer Nanopillars

Rasmus H. Pedersen, Qian Xu, John M. Stormonth‐Darling, Nikolaj Gadegaard

Macromolecular Materials and Engineering > 300 > 2 > 172 - 180

Injection moulding is a proven technology for high‐throughput production of nanostructures, but replication of raised structures is a considerable challenge, due to the complexities of cavity filling. We have developed a platform to systematically study the effects of nanostructures with aspect ratios up to 1.2:1. A master template containing nanostructures with a continuous variation in height is...

article

A novel, organic, UV-sensitive resist ideal for nanoimprint-, photo- and laser lithography in an air atmosphere

Andrew I. M. Greer, Nikolaj Gadegaard

Electronic Materials Letters > 2015 > 11 > 4 > 544-551

A UV-sensitive resist capable of curing in an oxygen atmosphere using single wavelength LED light sources is a niche area many UVnanoimprint lithography resists are incapable of addressing. However, the novel negative tone resist, presently (2015) known as DELOKATIOBOND OM VE 110707 (Delo-Katiobond), from Delo Industrial Adhesives has been designed to be specifically compatible with such conditions...

Publication date

Last 3 months (1)
Last year (3)
Last 3 years (6)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

NANOTOPOGRAPHY (5)
INJECTION MOLDING (4)
INJECTION MOULDING (4)
MECHANOTRANSDUCTION (3)
MICROFLUIDICS (3)
PLASMA POLYMERIZATION (3)
3D PRINTING (2)
ELECTRON BEAM LITHOGRAPHY (2)
FIBROBLAST (2)
FOCAL ADHESIONS (2)
HUMAN EMBRYONIC STEM CELLS (2)
LED (2)
MESENCHYMAL STEM CELLS (2)
NANOBIOSCIENCE (2)
NANOIMPRINT (2)
NANOSTRUCTURES (2)
ORGAN‐ON‐A‐CHIP (2)
PLASMA POLYMERISATION (2)
RESIST (2)
THERMOPLASTICS (2)
TISSUE ENGINEERING (2)
UV-NIL (2)
3D NANOPATTERNING (1)
ADDITIVE MANUFACTURE (1)
ADDITIVE MANUFACTURING (1)
ASTROCYTE (1)
BIOINFORMATICS (1)
BIOSENSING (1)
BODIPY (1)
BONE TISSUE ENGINEERING (1)
CARDIAC PHYSIOLOGY (1)
CELL CYCLE (1)
CELL IMPEDANCE SPECTROSCOPY (1)
CELL SENSING (1)
CELL SIGNALLING (1)
CELL VIABILITY (1)
CHIRAL PLASMONICS (1)
CLICK CHEMISTRY (1)
COMPUTATIONAL FLUID DYNAMICS (1)
CONDUCTING POLYMER ELECTRODES (1)
CONFORMAL RESIST COATING (1)
CONTINUOUS GLUCOSE MONITORING (CGM) (1)
CONTINUOUS LACTATE MONITORING (CLM) (1)
CROSS‐LINKING (1)
DISORDERED TOPOGRAPHY (1)
E-BEAM LITHOGRAPHY (1)
ELECTROPLATING (1)
ERK/MAPK (1)
ETCH (1)
EXTRACELLULAR-ACTIVATED PROTEIN KINASE (1)
FILOPODIA (1)
FINITE ELEMENT ANALYSIS (1)
FLASH (1)
FLASH IMPRINT (1)
FLUORESCENCE (1)
FRONT-LIGHT DISPLAY (1)
GENE EXPRESSION (1)
GENOMICS (1)
GRADIENTS (1)
GROWTH HORMONE (1)
HEXANE (1)
HIGH‐THROUGHPUT FABRICATION (1)
HOT EMBOSSING (1)
HSQ (1)
HYDROGEL (1)
IMPLANT (1)
IMPRINT (1)
INTERFACIAL STRUCTURE (1)
INTERSTITIAL THERAPEUTIC DRUG MONITORING (ITDM) (1)
INTESTINE (1)
LIGA (1)
LIVER MODEL (1)
MATHEMATICAL MODEL (1)
MDCK CELL CULTURE (1)
MESENCHYMAL STEM CELLS (MSCS) (1)
METAL (1)
METALLIZATION (1)
METAMATERIALS (1)
MICROFLUIDIC DEVICES (1)
MICRONEEDLES (1)
MICRO‐FABRICATION (1)
MINIMALLY INVASIVE SENSORS (1)
MOLECULAR BIOLOGY (1)
MSC (1)
NANO-PRINTING (1)
NANO-TOPOGRAPHY (1)
NANOLITHOGRAPHY (1)
NANOPATTERN (1)
NANOPATTERNS (1)
NANOTOPOLOGY (1)
NEUTRON REFLECTIVITY (1)
ORTHOPEDIC SCAFFOLDS (1)
OSTEOBLASTS (1)
OSTEOGENESIS (1)
OSTEOPROGENITOR CELLS (1)
OXYGEN (1)
OXYGEN CONCENTRATION GRADIENT (1)
PEDOT (1)
PEG (1)
PERFUSION CULTURE (1)
more

Data set

Elsevier (24)
ACS (16)
Wiley (15)
Springer (5)

Journal

Biomaterials (7)
Langmuir (7)
Microelectronic Engineering (7)
Advanced Engineering Materials (4)
Macromolecular Materials and Engineering (4)
The Journal of Physical Chemistry B (4)
Journal of Materials Science: Materials in Medicine (3)
Advanced Functional Materials (2)
Analytical Chemistry (2)
Journal of Vascular Surgery (2)
Journal of the American Chemical Society (2)
Advanced Materials (1)
Electronic Materials Letters (1)
European Polymer Journal (1)
Growth Hormone & IGF Research (1)
International Journal for Numerical Methods in Biomedical Engineering (1)
International Journal of Biochemistry and Cell Biology (1)
Journal of Cellular Biochemistry (1)
Journal of Electroanalytical Chemistry (1)
Nano Letters (1)
Nanoscale Research Letters (1)
Plasma Processes and Polymers (1)
Sensing and Bio-Sensing Research (1)
Sensors & Actuators: B. Chemical (1)
Sensors and Actuators A: Physical (1)
Tetrahedron (1)
The Journal of Physiology (1)
more

INFONA - science communication portal

Search results for: Nikolaj Gadegaard

Scalable, Transparent, and Micro: 3D‐Printed Rapid Tooling for Injection Molded Microfluidics

3D‐Printed Polyetheretherketone Smart Polymer Nanocomposite Scaffolds: Mechanical, Self‐Sensing, and Biological Attributes

3D‐Printed Polyetheretherketone Smart Polymer Nanocomposite Scaffolds: Mechanical, Self‐Sensing, and Biological Attributes

3D Printing and Rapid Replication of Advanced Numerically Generated Rough Surface Topographies in Numerous Polymers

Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell‐derived cardiomyocytes

3D Printed Tooling for Injection Molded Microfluidics

Flexible Inserts for Injection Molding of Complex Micro‐Structured Polymer Components

Modelling human liver microphysiology on a chip through a finite element based design approach

PC234 Promoting Endothelial Cell Adhesion by Modulation of Prosthetic Surface Topography at the Nano-Scale

Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

Fabrication of mesoscale topographical gradients in bulk titanium and their use in injection moulding

Characterisation of CorGlaes^® Pure 107 fibres for biomedical applications

Nanostructures: Enhanced Differentiation of Human Embryonic Stem Cells Toward Definitive Endoderm on Ultrahigh Aspect Ratio Nanopillars (Adv. Funct. Mater. 6/2016)

Enhanced Differentiation of Human Embryonic Stem Cells Toward Definitive Endoderm on Ultrahigh Aspect Ratio Nanopillars

Mechanical compatibility of sol–gel annealing with titanium for orthopaedic prostheses

Step-and-Repeat Nanoimprint-, Photo- and Laser Lithography from One Customised CNC Machine

Disposable Plasmonics: Plastic Templated Plasmonic Metamaterials with Tunable Chirality

Strategies for High Quality Injection Moulding of Polymer Nanopillars

A novel, organic, UV-sensitive resist ideal for nanoimprint-, photo- and laser lithography in an air atmosphere

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Nikolaj Gadegaard

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options