Search results for: Marie-Odile Bernier

Items from 1 to 16 out of 16 results

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Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: association between cardiac exposure and longitudinal strain reduction (BACCARAT study)

Valentin Walker, Olivier Lairez, Olivier Fondard, Atul Pathak, more

Radiation Oncology > 2019 > 14 > 1 > 1-11

Background Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction can be detected early after BC RT with global longitudinal strain (GLS) measurement based on 2D speckle-tracking echocardiography. This 6-month follow-up analysis from the BACCARAT prospective study aimed to investigate...

article

Reply to Natural history of thyroid cancer suggests beginning of the overdiagnosis of juvenile thyroid cancer in the United States and Harm of overdiagnosis or extremely early diagnosis behind trends in pediatric thyroid cancer

Marie‐Odile Bernier, Cari M. Kitahara, Meredith S. Shiels

Cancer > 125 > 22 > 4109 - 4110

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Is mean heart dose a relevant surrogate parameter of left ventricle and coronary arteries exposure during breast cancer radiotherapy: a dosimetric evaluation based on individually-determined radiation dose (BACCARAT study)

Sophie Jacob, Jérémy Camilleri, Sylvie Derreumaux, Valentin Walker, more

Radiation Oncology > 2019 > 14 > 1 > 1-10

Background Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosimetric study analyzes the distribution of individually-determined radiation doses to the heart and its substructures including coronary arteries and evaluate whether MHD is a relevant...

article

Occupational radiation exposure and risk of cataract incidence in a cohort of US radiologic technologists

Mark P. Little, Cari M. Kitahara, Elizabeth K. Cahoon, Marie-Odile Bernier, more

European Journal of Epidemiology > 2018 > 33 > 12 > 1179-1191

It has long been known that relatively high-dose ionising radiation exposure (> 1 Gy) can induce cataract, but there has been no evidence that this occurs at low doses (< 100 mGy). To assess low-dose risk, participants from the US Radiologic Technologists Study, a large, prospective cohort, were followed from date of mailed questionnaire survey completed during 1994–1998 to the earliest of self-reported...

article

Individual radiation exposure from computed tomography: a survey of paediatric practice in French university hospitals, 2010–2013

Neige M. Y. Journy, Serge Dreuil, Nathalie Boddaert, Jean-François Chateil, more

European Radiology > 2018 > 28 > 2 > 630-641

Objectives To describe computed tomography (CT) scanning parameters, volume CT dose index (CTDIvol) and dose-length product (DLP) in paediatric practice and compare them to current diagnostic reference levels (DRLs). Methods The survey was conducted in radiology departments of six major university hospitals in France in 2010–2013. Data collection was automatised to extract and standardise information...

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Early detection and prediction of cardiotoxicity after radiation therapy for breast cancer: the BACCARAT prospective cohort study

Sophie Jacob, Atul Pathak, Denis Franck, Igor Latorzeff, more

Radiation Oncology > 2016 > 11 > 1 > 1-10

Background Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring cardiac normal tissues within the irradiation field. Breast RT has been shown to be associated with long-term increased risk of heart failure, coronary artery disease, myocardial infarction...

article

Potential cancer risk associated with CT scans: Review of epidemiological studies and ongoing studies

Marie-Odile Bernier, Neige Journy, Hélène Baysson, Sophie Jacob, more

Progress in Nuclear Energy > 2015 > 84 > Complete > 116-119

The increasing use of computed tomography (CT) scans in paediatric population raises the question of a possible health impact of ionizing radiation exposure associated with CT scans.Three cohort studies have been recently published that have assessed the risk of cancer related to CT examinations of children and young adults. The methodology and results of these studies are presented, as are ongoing...

article

0174 : RadiothErapy for BrEast Cancer and early detection of CArdiotoxicity (REBECCA): a prospective cohort study

Sophie Jacob, Carole Massabeau, Olivier Lairez, Hervé Rousseau, more

Archives of Cardiovascular Diseases Supplements > 2015 > 7 > 2 > 176

Breast radiotherapy (RT) techniques used until the 1990s were responsible for increased mortality due to long term cardiac complications. Since the 2000s, improved techniques of RT have appeared leading to different dose distributions to organ at risks such as heart. But up to now, little is known on their cardiac toxicity. The aim of the REBECCA study is to evaluate whether helical tomotherapy (HT)...

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EpiBrainRad: an epidemiologic study of the neurotoxicity induced by radiotherapy in high grade glioma patients

Thomas Durand, Sophie Jacob, Laura Lebouil, Hassen Douzane, more

BMC Neurology > 2015 > 15 > 1 > 1-9

Background Radiotherapy is one of the most important treatments of primary and metastatic brain tumors. Unfortunately, it can involve moderate to severe complications among which leukoencephalopathy is very frequent and implies cognitive deficits such as memory, attention and executive dysfunctions. However, the incidence of this complication is not well established and the risk factors and process...

article

Predicted cancer risks induced by computed tomography examinations during childhood, by a quantitative risk assessment approach

Neige Journy, Sophie Ancelet, Jean-Luc Rehel, Myriam Mezzarobba, more

Radiation and Environmental Biophysics > 2014 > 53 > 1 > 39-54

The potential adverse effects associated with exposure to ionizing radiation from computed tomography (CT) in pediatrics must be characterized in relation to their expected clinical benefits. Additional epidemiological data are, however, still awaited for providing a lifelong overview of potential cancer risks. This paper gives predictions of potential lifetime risks of cancer incidence that would...

article

Exposure of the French paediatric population to ionising radiation from diagnostic medical procedures in 2010

Cécile Etard, Bernard Aubert, Myriam Mezzarobba, Marie-Odile Bernier

Pediatric Radiology > 2014 > 44 > 12 > 1588-1594

Background Medical examination is the main source of artificial radiation exposure. Because children present an increased sensitivity to ionising radiation, radiology practices at a national level in paediatrics should be monitored. Objective This study describes the ionising radiation exposure from diagnostic medical examinations of the French paediatric population in 2010. Materials and methods...

article

Interventional cardiologists and risk of radiation-induced cataract: Results of a French multicenter observational study

Sophie Jacob, Serge Boveda, Olivier Bar, Antoine Brézin, more

International Journal of Cardiology > 2013 > 167 > 5 > 1843-1847

Interventional cardiologists (ICs) are exposed to X-rays and may be at risk to develop cataract earlier than common senile cataract. Excess risk of posterior subcapsular cataract, known as radiation-induced, was previously observed in samples of ICs from Malaysia, and Latin America. The O'CLOC study (Occupational Cataracts and Lens Opacities in interventional Cardiology) was performed to quantify...

article

Eye lens radiation exposure and repeated head CT scans: A problem to keep in mind

Morgane Michel, Sophie Jacob, Gilles Roger, Béatrice Pelosse, more

European Journal of Radiology > 2012 > 81 > 8 > 1896-1900

The deterministic character of radiation-induced cataract is being called into question, raising the possibility of a risk in patients, especially children, exposed to ionizing radiation in case of repeated head CT-scans. This study aims to estimate the eye lens doses of a pediatric population exposed to repeated head CTs and to assess the feasibility of an epidemiological study.Children treated for...

article

304 Risk of occupational cataract in interventional cardiology: The O’CLOC study

Sophie Jacob, Olivier Bar, Serge Boveda, Christian Spaulding, more

Archives of Cardiovascular Diseases Supplements > 2010 > 2 > 1 > 98-99

Interventional cardiologists are repeatedly and acutely exposed to scattered ionizing radiations (X-rays) during their diagnostic or therapeutic procedures. These exposures may cause damages to the eye and induce early lens-opacities, known as radiation-induced cataracts.The O’CLOC study (Occupational Cataracts and Lens Opacities among Cardiologists) is the first epidemiological study designed to...

article

293 Risk assessment for radiation-induced cancer after Interventional Cardiology procedures

Sophie Jacob, Olivier Catelinois, Olivier Bar, Carlo Maccia, more

Archives of Cardiovascular Diseases Supplements > 2010 > 2 > 1 > 95

The increased use of interventional cardiology (IC) procedures, while providing important benefits to patients, also contributes to their radiation exposure. Radiation is a relatively weak carcinogen and demonstrating a radiation-induced cancer risk remains difficult. Only very crude results of lifetime risk assessment of cancer after IC procedures have been presented elsewhere, but the age distribution...

article

Prognostic value of an increase in the serum thyroglobulin level at the time of the first ablative radioiodine treatment in patients with differentiated thyroid cancer

Marie-Odile Bernier, Olivier Morel, Patrice Rodien, Jean-Pierre Muratet, more

European Journal of Nuclear Medicine and Molecular Imaging > 2005 > 32 > 12 > 1418-1421

Purpose The aim of this study was to assess the prognostic factors for treatment efficacy, and in particular the increase in serum thyroglobulin (Tg) level at the time of the first ablative radioiodine treatment, in patients with differentiated thyroid carcinoma (DTC). Methods A retrospective chart review was performed on 407 patients treated for DTC by total thyroidectomy and ¹³¹I ablation between...

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