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Tramadol has been used as an analgesic for several decades. µ-Opioid receptors (µORs) are the major receptors that mediate the analgesic effects of opioids. Although µORs have been thought to be one of the sites of action of tramadol, there has been no report that directly proves whether tramadol is an agonist of μOR or not. In this study, we examined the effects of tramadol and its main active metabolite...
This study compared trends in cured meat consumption in the U.S., to trends in cancer incidence rates by age, sex and race, between 1977-78 and 1989-91. Consumption of cured meat declined about 17%, with the decline more evident among whites than blacks. By the 1990s, average cured meat intake was over 20% higher among blacks than whites. Because residual nitrite in cured meats is reported to have...
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