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Background and purpose
Growth hormone (GH)/insulin‐like growth factor 1 (IGF‐1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN‐β) efficacy could be mediated also by an increase of IGF‐1 levels. A 2‐year longitudinal study was performed to estimate the prevalence of GH and/or IGF‐1 deficiency in clinically isolated syndrome (CIS) patients and...
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease due to mutations in SACS, which encodes sacsin, a protein localized on the mitochondrial surface and possibly involved in mitochondrial dynamics. In view of the possible mitochondrial involvement of sacsin, we investigated mitochondrial activity at functional and molecular level in skin fibroblasts obtained...
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