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Rearrangement of the T cell antigen receptor genes is a complex, highly regulated process. To gain a better understanding of the extracellular factors involved in the regulation of TCR β and y gene rearrangement in adult murine bone marrow-resident precursor T cells, sevveral cytokines were tested for their ability to induce gene recombination. A selected population of C58/J bone marrow cells (Thy...
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