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Jährlich erkranken etwa 9000 Frauen in Deutschland neu am Ovarialkarzinom. Der häufigste Subtyp ist das seröse „High-grade“-Ovarialkarzinom. Ein Teil der Ovarialkarzinome ist assoziiert mit einer Mutation von BRCA1 oder BRCA2 („breast and ovarian cancer susceptibility gen“); dies sind hochpenetrante Tumorsuppressorgene mit autosomalem Erbgang und Schlüsselgene in der DNA-Reparatur. Im überwiegenden...
At the University Hospital of Cologne, in general two patient groups at high risk for invasive aspergillosis receive posaconazole prophylaxis: Acute myelogenous leukaemia patients during remission induction chemotherapy and allogeneic haematopoietic stem cell transplant recipients. Other patients at risk undergo serum galactomannan testing three times weekly. At 72–96 h of persisting fever despite...
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