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Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD). On irradiation with visible light, PpIX undergoes phototransformation, producing photoproducts which may also be phototoxic and increase its efficacy. The mechanism of PpIX phototransformation...
Purpose: Binding of organic dyes with biosystems can provoke aggregation. This should change physico-chemical characteristics of both partners.Methods: This was demonstrated by optical absorption, fluorescence, 1 H NMR, ESR and resonance light scattering spectroscopies on the example of water soluble porphyrins and polychromophoric cyanine dyes in the presence of DNA and bovine serum albumin...
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