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Aims/hypothesis This study evaluates whether the non-selective β-blocker, carvedilol, can be used to prevent counterregulatory failure and the development of impaired awareness of hypoglycaemia (IAH) in recurrently hypoglycaemic rats. Methods Sprague Dawley rats were implanted with vascular catheters and intracranial guide cannulas targeting the ventromedial hypothalamus (VMH). These animals underwent...
Communication, i.e., moving data between levels of a memory hierarchy or between processors over a network, is much more expensive (in time or energy) than arithmetic. There has thus been a recent focus on designing algorithms that minimize communication and, when possible, attain lower bounds on the total number of reads and writes. However, most previous work does not distinguish between the costs...
Geometric multigrid solvers within adaptive mesh refinement (AMR) applications often reach a point where further coarsening of the grid becomes impractical as individual sub domain sizes approach unity. At this point the most common solution is to use a bottom solver, such as BiCGStab, to reduce the residual by a fixed factor at the coarsest level. Each iteration of BiCGStab requires multiple global...
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