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Aims/hypothesis Ketogenic diets (KDs) have increasingly gained attention as effective means for weight loss and potential adjunctive treatment of cancer. The metabolic benefits of KDs are regularly ascribed to enhanced hepatic secretion of fibroblast growth factor 21 (FGF21) and its systemic effects on fatty-acid oxidation, energy expenditure (EE) and body weight. Ambiguous data from Fgf21-knockout...
Background & Aims: Duodenal bicarbonate secretion is in part mediated by an apical Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down-regulated in adenoma) gene encodes a transport protein (DRA) for SO42−, Cl−, and HCO3−. The aim of this study was to investigate whether DRA may be the duodenal apical Cl−/HCO3− exchanger. Methods: DRA, Na+/H+ exchanger (NHE) isoform...
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