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Isoliquiritigenin (ISL, 1 ) and liquiritigenin (LTG, 2 ) were isolated from the rhizomes of Glycyrrhiza glabra . In an attempt to develop potent and selective antituberculosis agents, a series of ISL analogues were synthesized mainly via acid- and base-catalyzed Claisen–Schmidt condensation reaction for their antitubercular activity. Compared to ISL (MIC = 25 μg/mL),...
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