S. Vasireddy

article

Gamma‐tocotrienol as an effective agent in targeting prostate cancer stem cell‐like population

Sze Ue Luk, Wei Ney Yap, Yung‐Tuen Chiu, Davy TW Lee, more

International Journal of Cancer > 128 > 9 > 2182 - 2191

Emerging evidence supports that prostate cancer originates from a rare subpopulation of cells, namely prostate cancer stem cells (CSCs). Conventional therapies for prostate cancer are believed to mainly target the majority of differentiated tumor cells but spare CSCs, which may account for the subsequent disease relapse after treatment. Therefore, successful elimination of CSCs may be an effective...

article

Abstract No. 349: IVC size in the bariatric population: Implications for prophylactic IVC filter placement

T. Van Ha, T. Doshi, S. Vasireddy, R. Navuluri, more

Journal of Vascular and Interventional Radiology > 2011 > 22 > 3 Supplement > S144

article

Double-strand breaks and the concept of short- and long-term epigenetic memory

Christian Orlowski, Li-Jeen Mah, Raja S. Vasireddy, Assam El-Osta, more

Chromosoma > 2011 > 120 > 2 > 129-149

Double-strand breaks represent an extremely cytolethal form of DNA damage and thus pose a serious threat to the preservation of genetic and epigenetic information. Though it is well-known that double-strand breaks such as those generated by ionising radiation are among the principal causative factors behind mutations, chromosomal aberrations, genetic instability and carcinogenesis, significantly less...

article

Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks

Carl N. Sprung, Raja S. Vasireddy, Tom C. Karagiannis, Shanon J. Loveridge, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2010 > 692 > 1-2 > 49-52

The majority of cancer patients will receive radiotherapy (RT), therefore, investigations into advances of this modality are important. Conventional RT dose intensities are limited by adverse responses in normal tissues and a primary goal is to ameliorate adverse normal tissue effects. The aim of these experiments is to further our understanding regarding the mechanism of radioprotection by the DNA...

article

γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci

Raja S. Vasireddy, Tom C. Karagiannis, Assam El-Osta

Cellular and Molecular Life Sciences > 2010 > 67 > 2 > 291-294

The central dogma in radiation biology is that nuclear DNA is the critical target with respect to radiosensitivity. In accordance with the theoretical expectations, and in the absence of a conclusive model, the general consensus in the field has been to view chromatin as a homogeneous template for DNA damage and repair. This paradigm has been called into question by recent findings indicating a disparity...

article

Ten-year fracture probability identifies women who will benefit from clodronate therapy—additional results from a double-blind, placebo-controlled randomised study

E. V. McCloskey, H. Johansson, A. Oden, S. Vasireddy, more

Osteoporosis International > 2009 > 20 > 5 > 811-817

Summary Fracture risk prediction can be enhanced by the concurrent assessment of other clinical risk factors. This study demonstrates that the estimation of an individual’s 10-year probability of fracture by the FRAX® algorithm identifies patients at high risk of fracture who will respond to bisphosphonate therapy. Introduction Treatments for osteoporosis are targeted largely to patients with low...

article

Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate

K. Kayan, H. Johansson, A. Oden, S. Vasireddy, more

Osteoporosis International > 2009 > 20 > 12 > 2055-2061

Summary Fall risk does not significantly impact on the efficacy of the bisphosphonate clodronate in reducing the incidence of fracture. Introduction The debate about the efficacy of skeletal therapies on fracture risk in women at increased risk of falling continues. We determined whether fall risk impeded the efficacy of clodronate to reduce osteoporotic fracture incidence. Methods This is a post...

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Search results for: S. Vasireddy

Gamma‐tocotrienol as an effective agent in targeting prostate cancer stem cell‐like population

Abstract No. 349: IVC size in the bariatric population: Implications for prophylactic IVC filter placement

Double-strand breaks and the concept of short- and long-term epigenetic memory

Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks

γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci

Ten-year fracture probability identifies women who will benefit from clodronate therapy—additional results from a double-blind, placebo-controlled randomised study

Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate

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INFONA - science communication portal

Search results for: S. Vasireddy

Gamma‐tocotrienol as an effective agent in targeting prostate cancer stem cell‐like population

Abstract No. 349: IVC size in the bariatric population: Implications for prophylactic IVC filter placement

Double-strand breaks and the concept of short- and long-term epigenetic memory

Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks

γ-radiation-induced γH2AX formation occurs preferentially in actively transcribing euchromatic loci

Ten-year fracture probability identifies women who will benefit from clodronate therapy—additional results from a double-blind, placebo-controlled randomised study

Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate

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