Frank Marzinzik

article

Diplopia in Parkinson's disease: Indication of a cortical phenotype with cognitive dysfunction?

Wanda Naumann, Jacob Gogarten, Shideh Schönfeld, Fabian Klostermann, more

Acta Neurologica Scandinavica > 144 > 4 > 440 - 449

Background Visual disturbances are increasingly recognized as common non‐motor symptoms in Parkinson's disease (PD). In PD patients, intermittent diplopia has been found to be associated with the presence of visual hallucinations and the Parkinson's psychosis spectrum. Here, we investigated whether diplopia in PD is associated with other non‐motor traits and cognitive impairment. Methods We investigated...

article

Restless legs syndrome is a relevant comorbidity in patients with inflammatory bowel disease

Janek Becker, Felix Berger, Katharina A. Schindlbeck, Denis Poddubnyy, more

International Journal of Colorectal Disease > 2018 > 33 > 7 > 955-962

Background and aims In patients with inflammatory bowel disease (IBD), restless legs syndrome (RLS) may occur as an extraintestinal disease manifestation. Iron deficiency (ID) or folate deficiency/vitamin B₁₂ deficiency (FD/VB₁₂D) has previously been described to cause RLS. Here, we determined the prevalence and severity of RLS in IBD patients and evaluated the effect of iron and/or folic acid/vitamin...

article

Characterization of diplopia in non-demented patients with Parkinson's disease

Katharina A. Schindlbeck, Shideh Schönfeld, Wanda Naumann, David J. Friedrich, more

Parkinsonism & Related Disorders > 2017 > 45 > C > 1-6

Although diplopia is considered a frequent symptom of Parkinson's disease (PD), little is known about its clinical manifestation, associated mechanisms and treatment. Here we characterized binocular diplopia in non-demented PD patients in an interdisciplinary setting.PD patients were prospectively screened for diplopia, visual hallucinations, problems with spatial perception, contrast sensitivity,...

article

Rating of motor symptoms in Parkinson's disease – Different perspectives of the neurologist and the patient

Charlotte Rewitzer, Schindlbeck Katharina, André Maier, Fabian Klostermann, more

Basal Ganglia > 2017 > 8 > C > 2

article

Necessity of long‐term alertness in levodopa‐carbidopa intestinal gel infusion for PD patients

Fabian Klostermann, Christian Bojarski, Frank Marzinzik, André Maier, more

Movement Disorders > 32 > 2 > 300 - 301

article

Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life

Katharina A. Schindlbeck, Janek Becker, Felix Berger, Arne Mehl, more

International Journal of Colorectal Disease > 2017 > 32 > 1 > 125-130

Purpose Inflammatory bowel disease has been associated with neurological symptoms including restless legs syndrome. Here, we investigated the impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, mood, cognition, and quality of life. Methods Two groups of inflammatory bowel disease patients, with and without restless legs syndrome, were prospectively evaluated...

article

The single intake of levodopa modulates implicit learning in drug naïve, de novo patients with idiopathic Parkinson’s disease

Sarah Geffe, Katharina A. Schindlbeck, Arne Mehl, Johann Jende, more

Journal of Neural Transmission > 2016 > 123 > 6 > 601-610

Although dopamine is known to aggravate implicit learning, the exact impact on behaviour when feedback is unavailable remains unclear. Previous studies revealed that non-rewarded learning habits are affected in long-term dopaminergic treated patients with Parkinson’s disease (PD). We studied the influence of a onetime levodopa intake on implicit learning in de novo, untreated PD patients. De novo...

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Somatosensory symptoms in unmedicated de novo patients with idiopathic Parkinson’s disease

Katharina A. Schindlbeck, Arne Mehl, Sarah Geffe, Steffen Benik, more

Journal of Neural Transmission > 2016 > 123 > 3 > 211-217

Parkinson’s disease (PD) is a neurodegenerative condition presenting with motor and non-motor symptoms including somatosensory disturbances. As neuropathic syndromes in advanced PD patients are supposed to be due to antiparkinsonian medication, we studied the presence of somatosensory symptoms and peripheral nerve function in drug naïve patients with PD as well as age-matched healthy controls. Somatosensory...

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Dysfunctional action control as a specific feature of Parkinson’s disease

Frank Marzinzik, Anja Herrmann, Jacob H. Gogarten, Andreas Lueschow, more

Journal of Neural Transmission > 2015 > 122 > 8 > 1125-1133

Parkinson’s disease (PD) is characterised by motor deficits as well as cognitive alterations, particularly concerning frontal lobe control. Here, we were interested in whether executive function is abnormal already early in PD, as well as whether this dysfunction worsens as a part of the dementia in PD. The following groups engaged in tasks addressing action control: PD patients with mild and advanced...

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Severe gastrointestinal complications in patients with levodopa/carbidopa intestinal gel infusion

Fabian Klostermann, Constanze Jugel, Miriam Bömelburg, Frank Marzinzik, more

Movement Disorders > 27 > 13 > 1704 - 1705

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Malnutritional neuropathy under intestinal levodopa infusion

Fabian Klostermann, Constanze Jugel, Thomas Müller, Frank Marzinzik

Journal of Neural Transmission > 2012 > 119 > 3 > 369-372

Levodopa/Carbidopa intestinal gel infusion (LCIG) for Parkinson’s disease is under debate to provoke polyneuropathy (PNP). In our cohort of 20 thus treated patients, two developed debilitating axonal PNP with deficient pyridoxin and folate levels, and marginal cobalamin. Homocysteine was highly elevated. The neuropathies responded to vitamin replacement. We assume that LCIG can provoke PNP most likely...

article

Jejunal levodopa infusion in long‐term DBS patients with Parkinson's disease

Fabian Klostermann, Constanze Jugel, Frank Marzinzik

Movement Disorders > 26 > 12 > 2298 - 2299

article

Benefit from jejunal levodopa in a patient with apomorphine pump

Fabian Klostermann, Constanze Jugel, Frank Marzinzik

Journal of Neurology > 2011 > 258 > 2 > 311-312

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Speed effects of deep brain stimulation for Parkinson's disease

Fabian Klostermann, Michael Wahl, Frank Marzinzik, Jan Vesper, more

Movement Disorders > 25 > 16 > 2762 - 2768

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) accelerates reaction time (RT) in patients with Parkinson's disease (PD), particularly in tasks in which decisions on the response side have to be made. This might indicate that DBS speeds up both motor and nonmotor operations. Therefore, we studied the extent to which modifications of different processing streams could explain changes...

article

The Human Thalamus Processes Syntactic and Semantic Language Violations

Michael Wahl, Frank Marzinzik, Angela D. Friederici, Anja Hahne, more

Neuron > 2008 > 59 > 5 > 695-707

Numerous linguistic operations have been assigned to cortical brain areas, but the contributions of subcortical structures to human language processing are still being discussed. Using simultaneous EEG recordings directly from deep brain structures and the scalp, we show that the human thalamus systematically reacts to syntactic and semantic parameters of auditorily presented language in a temporally...

article

Executive control is disturbed in schizophrenia: evidence from event-related potentials in a Go/NoGo task - Go/No-Go discrimination

Matthias Weisbrod, Markus Kiefer, Frank Marzinzik, Manfred Spitzer

Biological Psychiatry > 2000 > 47 > 1 > 51-60

Background: Schizophrenic patients suffer from cognitive and attentional deficits, particularly from failure of executive control functions.Methods: This study investigated the cortical organization of executive control in schizophrenic patients and healthy control subjects using event-related potentials (ERPs). Event-related potentials were collected while subjects performed an auditory Go/NoGo task...

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Search results for: Frank Marzinzik

Diplopia in Parkinson's disease: Indication of a cortical phenotype with cognitive dysfunction?

Restless legs syndrome is a relevant comorbidity in patients with inflammatory bowel disease

Characterization of diplopia in non-demented patients with Parkinson's disease

Rating of motor symptoms in Parkinson's disease – Different perspectives of the neurologist and the patient

Necessity of long‐term alertness in levodopa‐carbidopa intestinal gel infusion for PD patients

Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life

The single intake of levodopa modulates implicit learning in drug naïve, de novo patients with idiopathic Parkinson’s disease

Somatosensory symptoms in unmedicated de novo patients with idiopathic Parkinson’s disease

Dysfunctional action control as a specific feature of Parkinson’s disease

Severe gastrointestinal complications in patients with levodopa/carbidopa intestinal gel infusion

Malnutritional neuropathy under intestinal levodopa infusion

Jejunal levodopa infusion in long‐term DBS patients with Parkinson's disease

Benefit from jejunal levodopa in a patient with apomorphine pump

Speed effects of deep brain stimulation for Parkinson's disease

The Human Thalamus Processes Syntactic and Semantic Language Violations

Executive control is disturbed in schizophrenia: evidence from event-related potentials in a Go/NoGo task - Go/No-Go discrimination

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