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Aims/hypothesis B cell CLL/lymphoma 2 (BCL-2)-interacting cell death suppressor (BIS), known as an anti-stress and anti-apoptotic protein, has been reported to modulate susceptibility to oxidative stress. This study investigated the potential role of BIS as an antioxidant protein in diabetic nephropathy. Methods Diabetes was induced in BIS-heterozygote (BIS-HT) mice via streptozotocin injections...
The Bcl‐2‐interacting death suppressor (Bis) protein is involved in antiapoptosis and antistress pathways. However, its roles after neonatal hypoxia–ischemia remain obscure. Therefore, we investigated the effects of Bis deletion on hippocampal cell death following neonatal hypoxia–ischemia. We transected the right common carotid artery of bis+/+ and bis−/− mice at postnatal Day 7 and subjected them...
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