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Several trials have demonstrated the important benefit of aldosterone, aldo, antagonists in patients with heart failure, HF, and the commonly accepted conclusion is that it is important to block aldo in every disease conditions. High doses of aldo generate myocardial fibrosis in the rat through pericoronary inflammatory reaction and necrosis. Low doses of aldo can be targeted in the myocardium by...
Objective: Cardiac myosin-binding protein C (cMyBP-C) gene mutations are involved in familial hypertrophic cardiomyopathy (FHC). Many of these mutations produce truncated proteins, which are unstable in the cardiac tissue of patients, suggesting that haploinsufficiency could account for the development of the phenotype. However, existing mouse models of cMyBP-C gene mutations have represented hypomorphic...
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