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High-pressure ventilation induces barotrauma and pulmonary inflammation, thus leading to ventilator-induced lung injury (VILI). By limiting the pulmonal inflammation cascade the anti-inflammatory cytokine interleukin (IL)-10 may have protective effects. Via inhalation, IL-10 reaches the pulmonary system directly and in high concentrations.Thirty six male, anesthetized and mechanically ventilated Sprague–Dawley...
Purpose We aimed at comparing the effects of intravenous (i.v.) and inhaled (inh.) levosimendan (LEVO) on survival, inflammatory cytokines and the apoptotic mediator caspase-3 in a rat model of severe sepsis induced by cecal ligation and incision (CLI). Methods Twenty-eight anesthetized/ventilated male Sprague–Dawley rats (body weight 528 ± 20 g) underwent laparotomy. Cecal mobilisation served as...
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