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Removal of the C‐propeptide from fibrillar procollagens is essential for collagen fibril assembly. The reaction is catalyzed by bone morphogenetic protein‐1/tolloid‐like proteinases and is accelerated by procollagen C‐proteinase enhancer 1 (PCPE‐1), an extracellular matrix glycoprotein that binds to the procollagen C‐propeptide and its expression overlaps that of collagen. Ascorbic acid (Asc) is vital...
The broad expression pattern of the G protein-coupled P2Y receptors has demonstrated that these receptors are fundamental determinants in many physiological responses, including neuromodulation, vasodilation, inflammation, and cell migration. P2Y receptors couple either Gq or Gi upon activation, thereby activating different signaling pathways. Ionotropic ATP (P2X) receptors bind extracellular nucleotides,...
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