Hongyu Piao

article

A Novel Surfactant-Free O/O Paclitaxel Ointment for the Topical Treatment of Psoriasis

Xiaozhuo Yin, Xiaolei Cao, Jiaqi Li, Xu Cheng, more

AAPS PharmSciTech > 2019 > 20 > 5 > 1-16

Psoriasis is an autoimmune disorder disease with pink-colored plaques and excessive proliferation which is hard to be cured completely. The study focuses on the anti-psoriatic efficacy of O/O paclitaxel ointment which can promote the assembly of microtubules and lead to death of overproliferation cells of the psoriasis epidermal. A high-speed shearing method was adopted in preparing the ointment,...

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Improved Oral Absorption of Poorly Soluble Curcumin via the Concomitant Use of Borneol

Ying Gao, Guo Chen, Xiaojiao Luan, Meijuan Zou, more

AAPS PharmSciTech > 2019 > 20 > 4 > 1-10

In this study, borneol, a natural active compound was applied to improve the bioavailability of curcumin (CUR). In order to increase CUR solubility and dissolution, solid dispersions (SDs) were prepared with the matrix of polyvinylpyrrolidone (PVP) at various ratios by solvent evaporation method. CUR was evidenced to exist as amorphous state in solid dispersion by differential scanning calorimetry...

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Phospholipid Complex of ICA and ICA II Prepared by Wet Media Milling for Improving Bioavailability

Caiyun Pan, Xiuxiu Cao, Lihua Tang, Yu Zhang, more

European Journal of Lipid Science and Technology > 120 > 4 > n/a - n/a

In order to enhance the lipophilicity and thus oral bioavailability of icariin (ICA) and icariside II (ICA II) of total flavonoids of epimedium (TFE), a total flavonoids of epimedium–phospholipid complex (TFE‐PLC) is prepared by wet media milling. The stabilizers Aerosi and SDS are used to formulate TFE‐PLC nanosuspensions (TFE‐PLC–Ns) to improve the dispersion of TFE–PLC. FTIR and DSC data confirms...

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A novel surface modified nitrendipine nanocrystals with enhancement of bioavailability and stability

Peng Quan, Kai Shi, Hongze Piao, Hongyu Piao, more

International Journal of Pharmaceutics > 2012 > 430 > 1-2 > 366-371

In this study, chitosan, a cationic polymer with positive charge, was introduced to modify the nanocrystals of nitrendipine with negative charge. The nanocrystals were prepared via precipitation–high pressure homogenization method. Then the nanocrystals were dispersed into chitosan solution, and the free chitosan was removed by centrifugation to obtain the chitosan modified nanocrystals, which remained...

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α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: Preparation, characterization and in vitro/in vivo evaluations

Na Liang, Shaoping Sun, Xuefeng Li, Hongze Piao, more

International Journal of Pharmaceutics > 2012 > 423 > 2 > 480-488

α-Tocopherol succinate hydrophobically modified chitosan (CS-TOS) containing 17 α-tocopherol groups per 100 anhydroglucose units was synthesized by coupling reaction. The formation of CS-TOS was confirmed by ¹ H NMR and FT-IR analysis. In aqueous medium, the polymer could self-aggregate to form micelles, and the critical micelle concentration (CMC) was determined to be 5.8×10 ⁻³ mg/ml...

article

Polymer-Mediated Anti-solvent Crystallization of Nitrendipine: Monodispersed Spherical Crystals and Growth Mechanism

Dengning Xia, Mei Ouyang, Jian X. Wu, Yanbo Jiang, more

Pharmaceutical Research > 2012 > 29 > 1 > 158-169

Purpose To investigate anti-solvent crystallization and growth mechanism of nitrendipine spherical crystals in an aqueous solution containing polymeric additives. Methods Size and shape of crystals were investigated using laser diffractometry, optical microscopy and scanning electron microscopy (SEM). Crystalline form was determined by X-ray powder diffractometer (XRPD). During crystal growth, morphological...

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Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation

Hongyu Piao, Noriho Kamiya, Fude Cui, Masahiro Goto

International Journal of Pharmaceutics > 2011 > 420 > 1 > 156-160

l-Ascorbic acid (AA, vitamin C) easily decomposes into inactive compounds in aqueous solutions and this has limited its topical use. This work reports the preparation of a solid-in-oil nanosuspension (SONS) containing AA and validation of its basic storage stability. Although AA itself is water-soluble, it can readily be nanosuspended in squalane via complex formation involving a combination of sucrose...

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In vitro–in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals

Hongyu Piao, Mei Ouyang, Dengning Xia, Peng Quan, more

International Journal of Pharmaceutics > 2011 > 419 > 1-2 > 255-259

The present work described the effect of CoQ10 dissolution characteristics in nanocrystals and lipid nanoparticles (LNs) on its oral absorption in rats. Nanocrystals and LNs were prepared by melt-high pressure homogenization and sucrose monolaurate was used as a stabilizer in all formulations. Witepsol ^® W35 and medium-chain triglycerides (MCT) were selected as lipid additives to form LN ...

article

Nitrendipine Nanocrystals: Its Preparation, Characterization, and In Vitro–In Vivo Evaluation

Peng Quan, Dengning Xia, Hongze Piao, Hongyu Piao, more

AAPS PharmSciTech > 2011 > 12 > 4 > 1136-1143

The present investigation was undertaken with the objective of developing a solid formulation containing nitrendipine nanocrystals for oral delivery. Nitrendipine nanocrystals were prepared using a tandem precipitation–homogenization process. Then, spray drying, a cost-effective method very popular in industrial situations, was employed to convert the nanocrystals into a solid form. The parameters...

article

Preparation of stable nitrendipine nanosuspensions using the precipitation–ultrasonication method for enhancement of dissolution and oral bioavailability

Dengning Xia, Peng Quan, Hongze Piao, Hongyu Piao, more

European Journal of Pharmaceutical Sciences > 2010 > 40 > 4 > 325-334

The aim of this study was to prepare and characterize nitrendipine nanosuspensions to enhance the dissolution rate and oral bioavailability of this drug. Nanosuspensions were prepared by the precipitation–ultrasonication method. The effects of five important process parameters, i.e. the concentration of PVA in the anti-solvent, the concentration of nitrendipine in the organic phase, the precipitation...

article

Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats

Dengning Xia, Fude Cui, Hongze Piao, Dongmei Cun, more

Pharmaceutical Research > 2010 > 27 > 9 > 1965-1976

Purpose To investigate the effect of crystal size on the dissolution and oral absorption of nitrendipine, a poorly soluble drug, in rats. Methods Five types of nitrendipine crystal suspensions with different particle sizes (200 nm, 620 nm, 2.7 μm, 4.1 μm, 20.2 μm) were prepared either by the precipitation-ultrasonication or the anti-solvent precipitation method. The simulated intestinal fluid in...

article

A solid-in-oil nanodispersion for transcutaneous protein delivery

Yoshiro Tahara, Shota Honda, Noriho Kamiya, Hongyu Piao, more

Journal of Controlled Release > 2008 > 131 > 1 > 14-18

Transcutaneous delivery attracts much attention but remains a challenging strategy for hydrophilic macromolecular drug administration. In the present study, we demonstrated that a solid-in-oil (S/O) nanodispersion, an oil-based nanodispersion of hydrophilic drugs, effectively enhanced the permeation of proteins into the skin. All of the different model proteins, FITC-labeled insulin (MW ca. 6 kDa),...

article

A Novel Solid-in-oil Nanosuspension for Transdermal Delivery of Diclofenac Sodium

Hongyu Piao, Noriho Kamiya, Akihiko Hirata, Takeru Fujii, more

Pharmaceutical Research > 2008 > 25 > 4 > 896-901

Purpose We formulated a solid-in-oil nanosuspension (SONS) as a novel transdermal delivery carrier for diclofenac sodium (DFNa). The basic transdermal characteristics of the SONS were evaluated using a Yucatan micropig (YMP) skin model. Methods DFNa-sucrose erucate (i.e. surfactant) complexes were prepared via the formation of a water-in-oil emulsion. The complexes were suspended in isopropyl myristate...

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Oral delivery of diclofenac sodium using a novel solid-in-oil suspension

Hongyu Piao, Noriho Kamiya, Junji Watanabe, Hideakira Yokoyama, more

International Journal of Pharmaceutics > 2006 > 313 > 1-2 > 159-162

The present work reports on a new pharmaceutical formulation for oral delivery of diclofenac sodium (DFNa), a non-steroidal anti-inflammatory drug (NSAID). Although DFNa itself is water-soluble at neutral pH, it was readily suspended in soybean oil via complex formation with an edible lipophilic surfactant and a matrix protein. The resulting solid-in-oil (S/O) suspension containing stably encapsulated...

INFONA - science communication portal

Search results for: Hongyu Piao

A Novel Surfactant-Free O/O Paclitaxel Ointment for the Topical Treatment of Psoriasis

Improved Oral Absorption of Poorly Soluble Curcumin via the Concomitant Use of Borneol

Phospholipid Complex of ICA and ICA II Prepared by Wet Media Milling for Improving Bioavailability

A novel surface modified nitrendipine nanocrystals with enhancement of bioavailability and stability

α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: Preparation, characterization and in vitro/in vivo evaluations

Polymer-Mediated Anti-solvent Crystallization of Nitrendipine: Monodispersed Spherical Crystals and Growth Mechanism

Preparation of a solid-in-oil nanosuspension containing l-ascorbic acid as a novel long-term stable topical formulation

In vitro–in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals

Nitrendipine Nanocrystals: Its Preparation, Characterization, and In Vitro–In Vivo Evaluation

Preparation of stable nitrendipine nanosuspensions using the precipitation–ultrasonication method for enhancement of dissolution and oral bioavailability

Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats

A solid-in-oil nanodispersion for transcutaneous protein delivery

A Novel Solid-in-oil Nanosuspension for Transdermal Delivery of Diclofenac Sodium

Oral delivery of diclofenac sodium using a novel solid-in-oil suspension

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