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Introduction We report a 16-year-old female with Melnick–Needles syndrome complicated with severe obstructive sleep apnea–hypoxia syndrome. Clinical report An overnight sleep study demonstrated that the patient had severe obstructive sleep apnea with an apnea–hypopnea index of 95/h. The lowest oxygen saturation was only 34%. The distraction osteogenesis technique was used to lengthen her mandible...