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We investigated analogues of GP2 (IISAVVGIL), an HLA-A*0201-restricted T-cell epitope derived from residues 654–662 in the tumor-associated antigen (TAA) Her-2/neu. One limiting factor of GP2 is its poor affinity for HLA-A*0201. Conformational analysis revealed the P5–P7 region in GP2 appears to be linked to the stability of P9 side chain interaction with the MHC molecule. To identify variants of...
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