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Glial cell line-derived neurotrophic factor (GDNF) increases choline acetyltransferase (ChAT) activity in the septohippocampal system of aged rats. Since the septohippocampal system has been implicated as a neurobiological substrate for spatial learning, the effects of GDNF were tested in aged, spatial learning-impaired Fisher 344 rats. Aged rats were characterized as spatial learning “impaired” or...
Original observations of the effects of stress exposure on behavioral, physiological and pathological indices were documented in the mid 1960s [J.B. Overmier, Interference with avoidance behavior: failure to avoid traumatic shock, J. Exp. Psychol. 78 (1968) 340-343; J.B. Overmier, M.E.P. Seligman, Effects of inescapable shock upon subsequent escape and avoidance learning, J. Comp. Physiol. Psychol...
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