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Cathepsin K is an osteoclast-derived cysteine protease that has been implicated as playing a major role in bone resorption. A substantial body of evidence indicates that cathepsin K is critical in osteoclast-mediated bone resorption and suggests that its pharmacological inhibition should result in inhibition of bone resorption in vivo. Here we report the pharmacological characterization of SB-462795...
. Hiatal disruption is one of the common mechanisms of failure after Nissen fundoplication. We investigated the correlation between various diaphragm stressors and disruption of the diaphragmatic closure. Thirty-seven patients with a hiatal hernia recurrence of 2 cm or greater, as proven by esophagram, endoscopy, or operative findings, were included. A retrospective analysis was conducted utilizing...
Objective and Design: The effects of two hydroxamate inhibitors of metalloproteinase and tumor necrosis factor α (TNFα) processing on endotoxin-induced plasma TNFα and arthritic lesions in adjuvant-induced arthritic (AA) rats were determined.¶Material and Treatment: BB-1101 and BB-1433 were administered orally twice daily to AA Lewis rats with an established disease (days 13 to 22). AA rats (day...
Abstract.Objective and Design: The effects of two hydroxamate inhibitors of metalloproteinase and tumor necrosis factor (TNF) processing on endotoxin-induced plasma TNF and arthritic lesions in adjuvant-induced arthritic (AA) rats were determined.Material and Treatment: BB-1101 and BB-1433 were administered orally twice daily to AA Lewis rats with an established disease (days 13 to 22). AA rats (day...
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