Search results for: Hidetaka Kobayashi

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chapter

Acrylamide in Japanese Processed Foods and Factors Affecting Acrylamide Level in Potato Chips and Tea

Mitsuru Yoshida, Hiroshi Ono, Yoshihiro Chuda, Hiroshi Yada, more

Advances in Experimental Medicine and Biology > Chemistry and Safety of Acrylamide in Food > 405-413

Acrylamide concentrations in processed foods sold in Japanese markets were analyzed by LC-MS/MS and GC-MS methods. Most potato chips and whole potato-based fried snacks showed acrylamide concentration higher than 1000 µg/kg. The concentrations in non-whole potato based Japanese snacks, including rice crackers and candied sweet potatoes, were less than 350 µg/kg. Those in instant precooked noodles...

article

Study of Double-strangeness Nuclear Systems with Nuclear Emulsion

Kazuma Nakazawa, Yoko Endo, Kaoru Hoshino, Hiroki Ito, more

Physics Procedia > 2015 > 80 > Complete > 69-73

Double strangeness nuclei such as double-Λ and Ξ hypernuclei have been studied with nuclear emulsion due to its fine position resolution. Recently, we have started an experiment to study Λ-Λ interaction more accurately than that information given by the NAGARA event with ∼10² double-Λ hypernuclei which may provide us understanding free from nuclear medium effect. It is necessary to develop treatment...

article

Essential oil variation of cultivated and wild Perilla analyzed by GC/MS

Miyuki Nitta, Hidetaka Kobayashi, Mayumi Ohnishi-Kameyama, Tsukasa Nagamine, more

Biochemical Systematics and Ecology > 2006 > 34 > 1 > 25-37

Twenty components extracted from the essential oil in the leaves of 172 samples of Perilla frutescens var. crispa (vegetable crop form), P. frutescens var. frutescens (oil crop form), the wild/weedy form of P. frutescens, and three wild Perilla species, Perilla citriodora, Perilla hirtella and Perilla setoyensis were analyzed using GC/MS. A wide range of essential oil components were found among the...

article

Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells

Izumi Konishi, Masashi Hosokawa, Tokutake Sashima, Hidetaka Kobayashi, more

Comparative Biochemistry and Physiology, Part C > 2006 > 142 > 1-2 > 53-59

The sea squirt Halocynthia roretzi metabolizes fucoxanthin, and subsequently accumulates its derived carotenoids with characteristic structures. In the present study, we isolated halocynthiaxanthin and fucoxanthinol as carotenoids having antiproliferative activity from H. roretzi. Halocynthiaxanthin and fucoxanthinol inhibited the growth of HL-60 human leukemia cells in a dose- and time-dependent...

article

Complete obstruction of the lower common bile duct caused by autoimmune pancreatitis: is biliary reconstruction really necessary?

Toshiki Matsubara, Yoichi Sakurai, Hirotake Miura, Hidetaka Kobayashi, more

Journal of Hepato-Biliary-Pancreatic Sciences > 2005 > 12 > 1 > 76-83

Recent observations suggest that an immune response is involved in the development of chronic pancreatitis. We report a case of autoimmune pancreatitis in a patient who showed complete obstruction of the lower common bile duct. A 63-year-old man was admitted to a local hospital, complaining of appetite loss and back pain. The patient had obstructive jaundice, and percutaneous transhepatic gallbladder...

article

Diversification of Multipurpose Plant, Perilla Frutescens

Miyuki Nitta, Ju Kyong Lee, Hidetaka Kobayashi, Dajun Liu, more

Genetic Resources and Crop Evolution > 2005 > 52 > 6 > 663-670

The traditional Asian crop, Perilla frutescens has multiple uses. There are specialized cultivars for seed oil and for medicinal use, as well as wild/weedy forms growing in various habitats. Based on selective characteristics of leaf odor, anthocyanin pigmentation, seed hardness and seed diameter, the diversity of this species was investigated to clarify the intraspecific differentiation. P. frutescens...

article

Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin α

Masayoshi Arai, Hitoshi Sato, Hidetaka Kobayashi, Masashi Suganuma, more

Biochemical and Biophysical Research Communications > 2004 > 317 > 3 > 817-822

Human T-cell leukemia-derived Jurkat cells are known to be defective in the G1 checkpoint. DNA-damaging agent bleomycin arrests the cell cycle at G2 phase of Jurkat cells, and microtubule-acting colchicine arrests it at the M phase. Simaomicin α, an actinomycete metabolite, itself showed no effect on the cell cycle status of Jurkat cells at least up to 6.0nM. However, the compound (0.6-6.0nM) was...

article

Comparative study of the product components of lipid oxidation in aqueous and organic systems

Hidetaka Kobayashi, Mitsuru Yoshida, Kazuo Miyashita

Chemistry and Physics of Lipids > 2003 > 126 > 1 > 111-120

Ethyl esters and phosphatidylcholines (PCs) of polyunsaturated fatty acids (PUFAs) were oxidized in organic solvents, aqueous emulsions, and liposomes in the presence of a radical inducer. Oxidation products and the positional distribution of monohydroperoxide (MHP) were determined by gas chromatography-mass spectrometry (GC-MS) analysis. The total amount of the oxidation products, of PUFA ethyl esters...

article

Formation of cleavage products by autoxidation of lycopene

Seon-Jae Kim, Eiichi Nara, Hidetaka Kobayashi, Junji Terao, more

Lipids > 2001 > 36 > 2 > 191-200

The cleavage products formed by autoxidation of lycopene were evaluated in order to elucidate possible oxidation products of lycopene in biological tissues. Lycopene solubilized at 50 μM in toluene, aqueous Tween 40, or liposomal suspension was oxidized by incubating at 37°C for 72 h. Among a number of oxidation products formed, eight products in the carbonyl compound fraction were identified as 3,7,11-trimethyl-2,4,6,10-dodecatetraen-1-al,...

article

Psoas abscess and cellulitis of the right gluteal region resulting from carcinoma of the cecum

Hidetaka Kobayashi, Yoichi Sakurai, Mitsutaka Shoji, Yasuko Nakamura, more

Journal of Gastroenterology > 2001 > 36 > 9 > 623-628

Although retroperitoneal or psoas abscess is an unusual clinical problem, the insidious and occult characteristics of this abscess sometimes cause diagnostic delays, resulting in considerably high morbidity and mortality. In particular, psoas abscess caused by perforated colon carcinoma is uncommon. We report a case of psoas abscess caused by a carcinoma of the cecum. A 72-year-old Japanese woman...

article

Inhibition of β-carotene-15,15'-dioxygenase activity by dietary flavonoids

Akihiko Nagao, Maki Maeda, Boey Peng Lim, Hidetaka Kobayashi, more

The Journal of Nutritional Biochemistry > 2000 > 11 > 6 > 348-355

β-Carotene-15,15'-dioxygenase is an enzyme responsible for providing vertebrates with vitamin A by catalyzing oxidative cleavage of β-carotene at its central double bond to two molecules of retinal in intestinal cells. However, little data have been reported regarding regulation of the enzyme activity. We have evaluated the effects of antioxidants and dietary flavonoids on the β-carotene dioxygenase...

article

The Development of an Elevated Lesion Associated with Colitis Cystica Profunda in the Transverse Colonic Mucosa During the Course of Ulcerative Colitis: Report of a Case

Yoichi Sakurai, Hidetaka Kobayashi, Hiroki Imazu, Shigeru Hasegawa, more

Surgery Today > 2000 > 30 > 1 > 69-73

Abstract: We report the case of a 53-year-old man with a long history of ulcerative colitis in whom an elevated lesion in the epithelium of the affected transverse colon was initially diagnosed as a benign inflammatory polyp by endoscopic biopsies. After 4 years of follow-up, because the tumor had enlarged and villous components were endoscopically observed on the surface, a colonic resection was...

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