Wyniki wyszukiwania dla: Samuel Cheshier

Pozycje od 1 do 11 spośród 11 wyników

artykuł

Molecular characterization of metachronous atypical teratoid rhabdoid tumors occurring in a young man 15 years apart

Carol S. Bruggers, Luke Linscott, Julieann C. Lee, Arie Perry, więcej

Pediatric Blood & Cancer > 70 > 1 > n/a - n/a

artykuł

Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant: clinical, radiologic, and histopathologic features

Calixto‐Hope G. Lucas, Javier E. Villanueva‐Meyer, Nicholas Whipple, Nancy Ann Oberheim Bush, więcej

Brain Pathology > 30 > 3 > 479 - 494

“Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant” is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I). Clinical outcomes and optimal treatment for this new tumor entity have yet to be defined....

artykuł

Evaluation of pediatric glioma outcomes using intraoperative MRI: a multicenter cohort study

Michael Karsy, S. Hassan Akbari, David Limbrick, Eric C. Leuthardt, więcej

Journal of Neuro-Oncology > 2019 > 143 > 2 > 271-280

Background The use of intraoperative MRI (iMRI) during treatment of gliomas may increase extent of resection (EOR), decrease need for early reoperation, and increase progression-free and overall survival, but has not been fully validated, particularly in the pediatric population. Objective To assess the accuracy of iMRI to identify residual tumor in pediatric patients with glioma and determine the...

artykuł

Pediatric parapharyngeal infection resulting in cervical instability and occipital-cervical fusion—case report and review of the literature

Yi-Ren Chen, Jon Sole, Rashad Jabarkheel, Michael Edwards, więcej

Child's Nervous System > 2019 > 35 > 5 > 893-895

Parapharyngeal infection is the most common deep neck space infection in children and, in rare instances, can result in bony destruction of the cervical spine. We report one such case that required occipital to cervical fusion and halo-vest fixation. We also review the literature and discuss the etiology, diagnosis, and treatment options for managing pediatric cervical bony destruction secondary to...

artykuł

Safety of Dynamic Magnetic Resonance Imaging of the Cervical Spine in Children Performed without Neurosurgical Supervision

Derek Yecies, Nathaniel Fogel, Michael Edwards, Gerald Grant, więcej

World Neurosurgery > 2018 > 116 > C > e1188-e1193

The need for neurosurgical supervision as well as the general safety and utility of dynamic magnetic resonance imaging (MRI) of the cervical spine in children remains controversial. We present the largest descriptive cohort study of cervical flexion-extension MRI scans in pediatric patients to help elucidate the safety and utility of this technique.We retrospectively reviewed all cervical spine MRI...

artykuł

Immunological low-dose radiation modulates the pediatric medulloblastoma antigens and enhances antibody-dependent cellular cytotoxicity

Arabinda Das, Daniel McDonald, Stephen Lowe, Amy-Lee Bredlau, więcej

Child's Nervous System > 2017 > 33 > 3 > 429-436

Background Immunotherapy can be an effective treatment for pediatric medulloblastoma (MB) patients. However, major subpopulations do not respond to immunotherapy, due to the lack of antigenic mutations or the immune-evasive properties of MB cells. Clinical observations suggest that radiation therapy (RT) may expand the therapeutic reach of immunotherapy. The aim of the present investigation is to...

artykuł

Ventricular endoscopy in the pediatric population: review of indications

Omar Choudhri, Abdullah H. Feroze, Jay Nathan, Samuel Cheshier, więcej

Child's Nervous System > 2014 > 30 > 10 > 1625-1643

Introduction Neuroendoscopy has greatly impacted pediatric neurosurgery over the past few decades. Improved optics and microsurgical tools have allowed neuroendoscopes to be used for a multitude of neurosurgical procedures. Discussion In this review article, we present the breadth of intraventricular neuroendoscopic procedures for the treatment of conditions ranging from hydrocephalus and brain...

artykuł

The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage

Michael Lim, Regina S. Bower, Ying Wang, Leroy Sims, więcej

Neurosurgical Review > 2012 > 35 > 3 > 413-419

Vasospasm is a major contributor to morbidity and mortality in aneurysmal subarachnoid hemorrhage (SAH), with inflammation playing a key role in its pathophysiology. Myeloperoxidase (MPO), an inflammatory marker, was examined as a potential marker of vasospasm in patients with SAH. Daily serum samples from patients with aneurysmal SAH were assayed for MPO, and transcranial Doppler (TCDs) and neurological...

artykuł

Highly enriched mesenchymal stem cells (MSC) can initiate sarcoma formation in vivo

Monika Tataria, Unsal Kuscuoglu, Ailles Lauire, Samuel Cheshier, więcej

Journal of the American College of Surgeons > 2006 > 203 > 3 Supplement > S39-S40

artykuł

αvβ3 Integrin in central nervous system tumors

Michael Lim, Samira Guccione, Terri Haddix, Leroy Sims, więcej

Human Pathology > 2005 > 36 > 6 > 665-669

α _v β ₃ is an integrin specifically expressed in endothelial cells of newly forming blood vessels. Integrin-mediated angiogenesis is hypothesized to play a central role in the development and the progression of central nervous system neoplasms. Accordingly, it is considered a potential target for antiangiogenic therapy. In the current study, we compare the expression of α _v ...

artykuł

RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines

Adrian M. Casillas, Andrew D. Thompson, Samuel Cheshier, Santiago Hernandez, więcej

Molecular Immunology > 1995 > 32 > 3 > 167-175

Expression of the recombination activating genes, RAG-1 and RAG-2, in lymphocytes, has been shown to depend on second messenger systems. An increase in intracellular cAMP upon stimulation with caffeine increases RAG expression while activation of protein kinase C (PKC) with phorbol myristate acetate (PMA) results in decreased RAG expression. The stringent regulation of recombination appears to be...

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