Search results for: Dhira Rani Saha

Items from 1 to 18 out of 18 results

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Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response

Bhupesh Kumar Thakur, Piu Saha, George Banik, Dhira Rani Saha, more

International Immunopharmacology > 2016 > 36 > C > 39-50

Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the intestine caused by dysregulated T-cell mediated immune response against commensal microflora. Probiotics are reported as therapeutically effective against IBD. However, variable efficacy of the live probiotic strains, difference in survival and persistence in the gut between the strains and the lack of insight into the mechanisms...

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Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India

Mou Ganguly, Sagartirtha Sarkar, Prachetash Ghosh, Avijit Sarkar, more

Gut Pathogens > 2016 > 8 > 1 > 1-10

Background Almost all Helicobacter pylori infected person develop gastritis and severe gastritis is supposed to be the denominator of peptic ulcer diseases, which may lead to gastric cancer. However, it is still an enigma why few strains are associated with ulcer formation, while others are not related with any disease outcome. Although a number of putative virulence factors have been reported for...

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Mo1755 Recombinant Accessory Cholera Enterotoxin (ACE) of Vibrio Cholera Induces Diarrhea by Stimulation of a Chloride Channel and Inhibition of the Na+/ Glucose Co-Transporter SGLT1

Irshad A. Sheikh, Tanaya Chatterjee, Mikio Hayashi, Dhira Rani Saha, more

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-652

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Comparative analysis of different oral approaches to treat Vibrio cholerae infection in adult mice

Abhishek Jaiswal, Hemanta Koley, Soma Mitra, Dhira Rani Saha, more

International Journal of Medical Microbiology > 2014 > 304 > 3-4 > 422-430

In this study, we have established an oral phage cocktail therapy in adult mice model and also performed a comparative analysis between phage cocktail, antibiotic and oral rehydration treatment for orally developed Vibrio cholerae infection. Four groups of mice were orally infected with Vibrio cholerae MAK 757 strain. Phage cocktail and antibiotic treated groups received 1×10⁸ plaque forming unit/ml...

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Outer membrane vesicles of Shigella boydii type 4 induce passive immunity in neonatal mice

Soma Mitra, Soumik Barman, Dhrubajyoti Nag, Ritam Sinha, more

FEMS Immunology & Medical Microbiology > 66 > 2 > 240 - 250

Like most other Gram‐negative bacteria, Shigella releases outer membrane vesicles (OMVs) into the surrounding environment during growth. In this study, we have exploited OMVs of Shigella as a protective immunogen in a mice model against Shigellosis. Distinctive vesicle secretion was noticed from different Shigella strains. Among them, Shigella boydii type 4 (BCH612) was secreting relatively higher...

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Live non‐invasive Shigella dysenteriae 1 strain induces homologous protective immunity in a guinea pig colitis model

Soumik Barman, Ranajit Kumar, Goutam Chowdhury, Dhira Rani Saha, more

Microbiology and Immunology > 55 > 10 > 683 - 693

A non‐invasive live transconjugant Shigella hybrid (LTSHΔstx) strain was constructed from a Shiga toxin gene deleted mutant of Shigella dysenteriae 1 by introducing a plasmid vector pPR1347 that carried a lipopolysaccharide biosynthesis gene (rfb and rfc) of Salmonella typhimurium. In guinea pigs, four successive oral administrations of LTSH Δstx showed complete protection against rectal challenge...

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Development of a new guinea‐pig model of shigellosis

Soumik Barman, Dhira Rani Saha, Thandavarayan Ramamurthy, Hemanta Koley

FEMS Immunology & Medical Microbiology > 62 > 3 > 304 - 314

Shigellosis is a major form of bacillary dysentery caused by Shigella spp. To date, there is no suitable animal model to evaluate the protective efficacy of vaccine candidates against this pathogen. Here, we describe a successful experimental shigellosis in the guinea‐pig model, which has shown the characteristic features of human shigellosis. This model yielded reproducible results without any preparatory...

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Effect of acute and chronic arsenic exposure on growth, structure and virulence of Aeromonas hydrophila isolated from fish

Ramansu Goswami, Debabrata Ghosh, Dhira Rani Saha, Pratap Kumar Padhy, more

Microbial Pathogenesis > 2011 > 50 > 2 > 63-69

Aeromonas hydrophila being a ubiquitous bacterium is prone to arsenic exposure. The present study was designed to determine the role of arsenic on growth and virulence of A. hydrophila. Exposure to arsenic (1 mg L ⁻¹ and 2 mg L ⁻¹ ) had no effect on growth but significantly inhibited the hemolytic and cytotoxic potential of exposed bacteria. Transmission electron microscopy revealed...

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Immunogenicity and protective efficacy of Vibrio cholerae outer membrane vesicles in rabbit model

Nivedita Roy, Soumik Barman, Amit Ghosh, Amit Pal, more

FEMS Immunology & Medical Microbiology > 60 > 1 > 18 - 27

We show here that oral immunization with purified outer membrane vesicles (OMVs) of Vibrio cholerae induces a prolonged high rise in the protective antibody titre. Rabbit immune sera were vibriocidal against the homologous and against several heterologous V. cholerae strains in vitro. In addition, OMV immunization conferred significant protective immunity against subsequent bacterial challenges. Thirty...

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Selective Deletion of CD8⁺ Cells Upregulated by Caspases-1 via IL-18 in Mice Immunized with Major Outer Membrane Protein of Shigella dysenteriae 1 Following Infection

Ashim Kumar Bagchi, Ajoy Kumar Sinha, Rushita Adhikari, Pradip Maiti, more

Journal of Clinical Immunology > 2010 > 30 > 3 > 408-418

Introduction Mucosal lymphoid changes were observed in cryopreserved rectal tissues obtained from BALB/c mice infected with Shigella dysenteriae 1, immunized with 57-kDa major antigenic outer membrane protein, and infection after immunization. Discussion Our data suggested that caspase-3 is downregulated in CD4⁺ cells of immunized BALB/c mice following infection with substantial increased expression...

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Pathogenic potential of vibriophages against an experimental infection with Vibrio cholerae O1 in the RITARD model

Tushar Suvra Bhowmick, Hemanta Koley, Mayukh Das, Dhira Rani Saha, more

International Journal of Antimicrobial Agents > 2009 > 33 > 6 > 569-573

Cholera continues to be an important public health problem in developing countries, including India. This study concerns the feasibility of possible exploitation of bacteriophages as a biocontrol agent to eliminate the pathogen Vibrio cholerae from the gut using the removable intestinal tie–adult rabbit diarrhoea (RITARD) model. A control rabbit challenged with 10 ⁹ colony-forming units (CFU)/mL...

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Chronic exposure to low concentration of arsenic is immunotoxic to fish: Role of head kidney macrophages as biomarkers of arsenic toxicity to Clarias batrachus

Soma Datta, Debabrata Ghosh, Dhira Rani Saha, Shelley Bhattacharaya, more

Aquatic Toxicology > 2009 > 92 > 2 > 86-94

The present study was aimed at elucidating the effect of chronic low-level arsenic exposure on the head kidney (HK) of Clarias batrachus and at determining the changes in head kidney macrophage (HKM) activity in response to arsenic exposure. Chronic exposure (30 days) to arsenic (As ₂ O ₃ , 0.50μM) led to significant increase in arsenic content in the HK accompanied by reduction in...

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Virulence plasmid of Aeromonas hydrophila induces macrophage apoptosis and helps in developing systemic infection in mice

Tanmay Majumdar, Pritam Chattopadhyay, Dhira Rani Saha, Subrato Sau, more

Microbial Pathogenesis > 2009 > 46 > 2 > 98-107

Pathogenic Aeromonas hydrophila Strain AO1 bears a 21kb plasmid encoding several virulence determinants. Infection studies revealed that this isolate induced cytotoxicity in BALB/c mice splenic macrophages involving reactive oxygen species generation. DNA gel, Hoechst 33342, annexin-V and TUNEL assay documented macrophage death induced by 21kb plasmid bearing isolates to be apoptotic in nature. Apoptosis...

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The efficacy and immunogenicity of a live transconjugant hybrid strain of Shigella dysenteriae type 1 in two animal models

Hemanta Koley, Soumik Barman, Nivedita Roy, Dhira Rani Saha, more

World Journal of Microbiology and Biotechnology > 2009 > 25 > 4 > 679-686

In our earlier studies, we constructed a hybrid strain of Shigella dysenteriae type 1 by introducing a plasmid vector pPR 1347. After introduction of a lipopolysaccharide (LPS) biosynthesis gene, virulent Shigella dysenteriae type 1 strain became avirulent. In our present study, we have evaluated the immune response and protective efficacy of avirulent live transconjugant Shigella hybrid (LTSH) strain...

article

Sub-lethal concentration of arsenic interferes with the proliferation of hepatocytes and induces in vivo apoptosis in Clarias batrachus L.

Soma Datta, Dhira Rani Saha, Debabrata Ghosh, Tanmay Majumdar, more

Comparative Biochemistry and Physiology, Part C > 2007 > 145 > 3 > 339-349

We studied the hepatocellular alterations induced by sub-lethal concentrations (0.50 μM) of arsenic in Indian catfish Clarias batrachus L. Sub-lethal arsenic exposure altered serum aspartate aminotransferase and alkaline phosphatase levels and brought about significant changes in different serum biochemical parameters. Arsenic exposure reduced total hepatocyte protein content and suppressed the proliferation...

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Molecular epidemiology of human picobirnaviruses among children of a slum community in Kolkata, India

Rittwika Bhattacharya, Ganesh C. Sahoo, Mukti K. Nayak, Dhira Rani Saha, more

Infection, Genetics and Evolution > 2006 > 6 > 6 > 453-458

Picobirnaviruses are a group of unclassified, non-enveloped, small spherical viruses, 35–41nm in diameter without any apparent surface morphology. They have characteristic bisegmented double stranded RNA genome of two types namely large profile (2.3–2.6kbp for the larger and 1.5–1.9kbp for the smaller segment, respectively) or small profile (1.75 and 1.55kbp for segments 1 and 2, respectively). Human...

article

Mitochondrial oxidative stress and permeability transition in Isoniazid and Rifampicin induced liver injury in mice

Abhijit Chowdhury, Amal Santra, Koutilya Bhattacharjee, Subhadip Ghatak, more

Journal of Hepatology > 2006 > 45 > 1 > 117-126

To evaluate the role of mitochondrial oxidative stress and permeability transition (MPT) in isoniazid (INH) and rifampicin (RMP) induced hepatotoxicity in mice.Liver damage was induced by co-treatment of INH (50mg/kg) and RMP (100mg/kg). Pre-treatment with either methionine or phorone was done to modulate hepatic GSH level. Liver cell injury was assessed biochemically and histologically.Evidence of...

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Histopathological study of rabbit intestinal mucosa infected with a hybrid strain of Shigella dysenteriae 1 carrying LPS biosynthesis genes of Salmonella enterica serovar typhimurium

Dipak Kumar Hens, Dhira Rani Saha, Subarna Ray, Debabrata Biswas, more

FEMS Microbiology Letters > 2003 > 219 > 2 > 215-218

The rfb gene cluster and the rfc gene of Salmonella enterica were introduced earlier into an invasive Shigella dysenteriae 1 strain by triparental cross. Antiserum was raised in rabbit against lipopolysaccharide isolated from the hybrid strain. Both the hybrid and the invasive S. dysenteriae 1 strain were found to have a titer of 1:2560 while for S. enterica, it was 1:640. Ligated ileal loops were...

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