Search results for: Young Hye Kwon

Items from 1 to 12 out of 12 results

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Altered lipid metabolism in rat offspring of dams fed a low-protein diet containing soy protein isolate

Mi Yoon, Sae Bom Won, Young Hye Kwon

Life Sciences > 2017 > 174 > Complete > 1-7

Substantial studies have reported that maternal protein restriction may induce later development of cardiovascular disease in offspring by impairing antioxidant system and lipid metabolism. Because a unique amino acid composition of soy protein isolate has been shown to provide health benefits, including hypolipidemic effects, we investigated effects of maternal low-protein diet composed of low-isoflavone...

article

Maternal consumption of low-isoflavone soy protein isolate alters hepatic gene expression and liver development in rat offspring

Sae Bom Won, Anna Han, Young Hye Kwon

The Journal of Nutritional Biochemistry > 2017 > 42 > C > 51-61

In utero environment is known to affect fetal development. Especially, the distinct fetal programming of carcinogenesis was reported in offspring exposed to maternal diets containing soy protein isolate (SPI) or genistein. Therefore, we investigated whether maternal consumption of low-isoflavone SPI or genistein alters hepatic gene expression and liver development in rat offspring. Female Sprague–Dawley...

article

Homocysteine induces PUMA-mediated mitochondrial apoptosis in SH-SY5Y cells

Yumi Jang, Juhae Kim, Je Won Ko, Young Hye Kwon

Amino Acids > 2016 > 48 > 11 > 2559-2569

Previous studies have reported that homocysteine induced endoplasmic reticulum (ER) stress in neuronal cells, proposing the underlying mechanism by which it could induce neurotoxicity. Induction of pro-apoptotic transcription factor C/EBP homologous protein (CHOP) and activation of caspase-4 by calpain have been suggested to be an important route in inducing apoptosis in response to ER stress. In...

article

Genistein alleviates the development of nonalcoholic steatohepatitis in ApoE^―/― mice fed a high‐fat diet

Sookyoung Jeon, Youn‐Jin Park, Young Hye Kwon

Molecular Nutrition & Food Research > 58 > 4 > 830 - 841

ScopeGenistein (GEN) is a compound that has been shown to alleviate hepatic steatosis. Here, we investigated its protective effects against non‐alcoholic steatohepatitis (NASH) development in apolipoprotein E‐deficient (ApoE^―/―) mice fed a high‐fat diet (HFD). Methods and resultsWild‐type and ApoE^―/― mice were fed an HFD with or without GEN (0.5 g/kg diet) for 24 weeks. Body weights were reduced...

article

Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects

Mi-hyun Kim, Junghun Lee, Kyungjin Jung, Minjung Kim, more

Bioorganic & Medicinal Chemistry > 2013 > 21 > 8 > 2271-2285

1-Heteroaryl-2-aryl-1H-benzimidazole derivatives were synthesized as inhibitors of c-Jun N-terminal kinases, JNK3. Their activities were evaluated through measurement of K_d using SPR, JNK3 kinase assay, and cell-viability of human neuroblastoma cells. Most tested compounds showed high affinity (10μM–46nM) to JNK3. Among them, compound 16f exhibited potent activities (K_d=46nM). Especially, 16f was...

article

Activation of AMP-Activated Protein Kinase Alleviates Homocysteine-Mediated Neurotoxicity in SH-SY5Y Cells

Youn-Jin Park, Je Won Ko, Yumi Jang, Young Hye Kwon

Neurochemical Research > 2013 > 38 > 8 > 1561-1571

Mammalian AMP-activated protein kinase (AMPK) acts as a metabolite-sensing protein kinase in multiple tissues. Recent studies have shown that AMPK activation also regulates intracellular signaling pathways involved in cellular survival and apoptosis. Previously, we have reported that AMPK activation alleviates the endoplasmic reticulum (ER) stress-mediated neurotoxicity and tau hyperphosphorylation...

article

The protective effect of genistein against ER stress-mediated neuronal degeneration in ApoE-/- mice fed a high-fat diet

Young Hye Kwon, Park Youn-Jin, Soo Kyoung Jeon

Alzheimer's & Dementia > 2012 > 8 > 4(S) > S769

article

AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells

Juhae Kim, Youn-Jin Park, Yumi Jang, Young Hye Kwon

Brain Research > 2011 > 1418 > Complete > 42-51

Obesity and diabetes have been shown to be associated with cognitive impairment or early neurodegeneration. However, the cellular mechanisms that link between these two pathologies have not been clarified. In this study, we treated SH-SY5Y human neuroblastoma cells with palmitate and observed its effect on cell apoptosis and tau hyperphosphorylation. Dose- and time-dependent effects of palmitate on...

article

Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells

Jin-young Lee, Hyang-Ki Cho, Young Hye Kwon

Metabolism > 2010 > 59 > 7 > 927-934

Previous studies showed that increased release of free fatty acids from adipocytes leads to insulin resistance and triglyceride (TG) accumulation in the liver, which may progress into hepatic steatohepatitis. We and other investigators have previously reported that palmitate induces endoplasmic reticulum stress-mediated toxicity in several tissues. This work investigated whether palmitate could induce...

article

Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells

Youn-Jin Park, Yumi Jang, Young Hye Kwon

Amino Acids > 2010 > 39 > 3 > 785-794

Previously, we reported that isoflavones exert a protective effect against the endoplasmic reticulum (ER) stress-mediated neuronal degeneration, and ER stress-mediated homocysteine toxicity may play an important role in the pathogenesis of neurodegeneration. Therefore, in this study we investigated the effects of isoflavones (genistein and daidzein) against homocysteine-mediated neurotoxicity in SH-SY5Y...

article

Synergistic induction of ER stress by homocysteine and β-amyloid in SH-SY5Y cells

Hyun-Jung Kim, Hyang-Ki Cho, Young Hye Kwon

The Journal of Nutritional Biochemistry > 2008 > 19 > 11 > 754-761

Clinical studies have raised the possibility that elevated plasma levels of homocysteine increase the risk of atherosclerosis, stroke and possibly neurodegenerative diseases such as Alzheimer's disease (AD); however, the direct impact of homocysteine on neuron cells and the mechanism by which it could induce neurodegeneration have yet to be clearly demonstrated. Here, we investigated the effect of...

article

Differential regulation of the CDK inhibitor p27 (KIP1) following CCL4 induced liver injury

Angela L. Tyner, Young Hye Kwon, Hiroaki Kiyokawa, Michael S. Serfas

Gastroenterology > 2000 > 118 > 4 Part 1 > A921

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