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Background Cytoplasmic and nuclear accumulation of β-catenin in mucoepidermoid carcinoma (MEC) is frequently noted, but the mechanism is unknown. Methods The methylation status of adenomatous polyposis coli (APC) and secreted frizzled-related proteins (SFRPs) was examined by methylation-specific polymerase chain reaction (MSP) assay. The association of SFRP1, β-catenin, and cyclin D1 expression...