Search results for: N. N. Chernov

Items from 1 to 10 out of 10 results

article

Role of MicroRNAs in the Regulation of Redox-Dependent Processes

E. V. Kalinina, V. I. Ivanova-Radkevich, N. N. Chernov

Biochemistry (Moscow) > 2019 > 84 > 11 > 1233-1246

Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement...

article

Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin

E. V. Kalinina, Y. A. Andreev, A. S. Petrova, K. I. Lubova, more

Bulletin of Experimental Biology and Medicine > 2018 > 165 > 5 > 678-681

Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor...

article

A Method of Body Shape Optimization for Decreasing the Aerodynamic Drag Force in Gas Flow

N. N. Chernov, A. V. Palii, A. V. Saenko, A. M. Maevskii

Technical Physics Letters > 2018 > 44 > 4 > 328-330

Aerodynamic flow past bodies of various geometrical shapes was studied, and the aerodynamic drag force was reduced through optimization of the body shape using a specially proposed method. The resulting drag force was compared to that for bodies formed by revolution of the profiles of well-known standard series. The study was performed using the Ansys Fluent software for isothermal laminar steady-state...

article

Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes

E. V. Kalinina, N. N. Chernov, M. D. Novichkova

Biochemistry (Moscow) > 2014 > 79 > 13 > 1562-1583

Over the last decade fundamentally new features have been revealed for the participation of glutathione and glutathione-dependent enzymes (glutathione transferase and glutaredoxin) in cell proliferation, apoptosis, protein folding, and cell signaling. Reduced glutathione (GSH) plays an important role in maintaining cellular redox status by participating in thiol-disulfide exchange, which regulates...

article

Expression of Genes of Glutathione Transferase Isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in Tumor Cells during the Formation of Drug Resistance to Cisplatin

E. V. Kalinina, T. T. Berozov, A. A. Shtil, N. N. Chernov, more

Bulletin of Experimental Biology and Medicine > 2012 > 154 > 1 > 64-67

We studied the expression of genes encoding glutathione-S-transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 during the development of the resistance of human erythroleukemia (K562), mammary adenocarcinoma (MCF-7) and ovary adenocarcinoma (SKOV-3) cells to cisplatin (CDDP). It was found that drug resistance development in all three strains of tumor cells is associated with signifi cant increase in...

article

Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation

E. V. Kalinina, T. T. Berezov, A. A. Shtil’, N. N. Chernov, more

Bulletin of Experimental Biology and Medicine > 2012 > 153 > 6 > 879-882

We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms...

article

Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cell during the development doxorubicin resistance

E. V. Kalinina, N. N. Chernov, A. N. Saprin, Ya. N. Kotova, more

Bulletin of Experimental Biology and Medicine > 2007 > 143 > 3 > 328-330

Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cells K562, MCF-7, and SKOV-3 was studied during the development of resistance to doxorubicin. It was found that the development of resistance was accompanied by predominant increase in the expression of hGSTP1 gene in MCF-7 cells, and hGSTA4 gene in resistant K562/DOX and SKVLB cells.

article

Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB

E. V. Kalinina, N. N. Chernov, A. N. Saprin, Ya. N. Kotova, more

Bulletin of Experimental Biology and Medicine > 2007 > 144 > 3 > 301-303

The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression.

article

SNP-detecting DNA technologies: Solving problems of applied biochemistry

I. N. Krakhmaleva, S. S. Shishkin, N. I. Shakhovskaya, E. B. Stolyarova, more

Applied Biochemistry and Microbiology > 2005 > 41 > 3 > 264-268

The heterozygosity of CANP3, ACTN3, and GHR genes in specialized collections was studied using state-of-the-art DNA technologies for DNA analysis. A new dinucleotide deletion (AC) at the beginning of exon 21 was identified in five individuals with a heterozygous CANP3 gene. Analysis of polymorphism (1747 C → T) of the ACTN3 gene demonstrated a positive association of allele C with high muscular performance...

article

The Status Report of the LNPI 1 GeV Synchrocyclotron

N. N. Chernov

IEEE Transactions on Nuclear Science > 1973 > 20 > 3 > 263 - 265

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Search results for: N. N. Chernov

Role of MicroRNAs in the Regulation of Redox-Dependent Processes

Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin

A Method of Body Shape Optimization for Decreasing the Aerodynamic Drag Force in Gas Flow

Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes

Expression of Genes of Glutathione Transferase Isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in Tumor Cells during the Formation of Drug Resistance to Cisplatin

Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation

Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cell during the development doxorubicin resistance

Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB

SNP-detecting DNA technologies: Solving problems of applied biochemistry

The Status Report of the LNPI 1 GeV Synchrocyclotron

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