Search results for: Michael J. Sanderson

Items from 1 to 20 out of 32 results

article

Evolution of l‐DOPA 4,5‐dioxygenase activity allows for recurrent specialisation to betalain pigmentation in Caryophyllales

Hester Sheehan, Tao Feng, Nathanael Walker‐Hale, Samuel Lopez‐Nieves, more

The evolution of l‐DOPA 4,5‐dioxygenase activity, encoded by the gene DODA, was a key step in the origin of betalain biosynthesis in Caryophyllales. We previously proposed that l‐DOPA 4,5‐dioxygenase activity evolved via a single Caryophyllales‐specific neofunctionalisation event within the DODA gene lineage. However, this neofunctionalisation event has not been confirmed and the DODA gene lineage...

article

Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma

Jun Chen, Marina Miller, Hirotoshi Unno, Peter Rosenthal, more

Journal of Allergy and Clinical Immunology > 2018 > 142 > 1 > 207-218.e6

Airway hyperresponsiveness is a major feature of asthma attributed predominantly to an extrinsic immune/inflammatory response increasing airway smooth muscle (ASM) contractility.We investigated whether increased ASM expression of orosomucoid-like 3 (ORMDL3), a gene on chromosome 17q21 highly linked to asthma, induced increased ASM proliferation and contractility in vitro and influenced airway contractility...

article

The prevalence of terraced treescapes in analyses of phylogenetic data sets

Barbara H. Dobrin, Derrick J. Zwickl, Michael J. Sanderson

BMC Evolutionary Biology > 2018 > 18 > 1 > 1-16

Background The pattern of data availability in a phylogenetic data set may lead to the formation of terraces, collections of equally optimal trees. Terraces can arise in tree space if trees are scored with parsimony or with partitioned, edge-unlinked maximum likelihood. Theory predicts that terraces can be large, but their prevalence in contemporary data sets has never been surveyed. We selected 26...

article

Store‐operated calcium entry is required for sustained contraction and Ca²⁺ oscillations of airway smooth muscle

Jun Chen, Michael J. Sanderson

The Journal of Physiology > 595 > 10 > 3203 - 3218

Key points Airway hyper‐responsiveness in asthma is driven by excessive contraction of airway smooth muscle cells (ASMCs). Agonist‐induced Ca²⁺ oscillations underlie this contraction of ASMCs and the magnitude of this contraction is proportional to the Ca²⁺ oscillation frequency. Sustained contraction and Ca²⁺ oscillations require an influx of extracellular Ca²⁺, although the mechanisms and pathways...

article

The relative contributions of store‐operated and voltage‐gated Ca²⁺ channels to the control of Ca²⁺ oscillations in airway smooth muscle

Sebastian Boie, Jun Chen, Michael J. Sanderson, James Sneyd

The Journal of Physiology > 595 > 10 > 3129 - 3141

Key points Agonist‐dependent oscillations in the concentration of free cytosolic calcium are a vital mechanism for the control of airway smooth muscle contraction and thus are a critical factor in airway hyper‐responsiveness. Using a mathematical model, closely tied to experimental work, we show that the oscillations in membrane potential accompanying the calcium oscillations have no significant...

chapter

MRF Supertrees

J. Gordon Burleigh, Oliver Eulenstein, David Fernández-Baca, Michael J. Sanderson

Computational Biology > Phylogenetic Supertrees > Reviews of existing methods > 65-85

We survey and present new results and techniques for the supertree method matrix representation using flipping (MRF). The method resolves inconsistencies among the input trees by working with the matrix representations of the clusters exhibited by the input trees. All inconsistencies between the clusters in the matrix are resolved by a minimum number of flips, where each flip moves a taxon into or...

chapter

Ca²⁺ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle Cells

Michael J. Sanderson, Yan Bai, Jose Perez-Zoghbi

Advances in Experimental Medicine and Biology > Membrane Receptors, Channels and Transporters in Pulmonary Circulation > Ion Channels in the Pulmonary Vasculature: Basics and New Findings > 77-96

Pulmonary blood pressure is a function of the resistance of the intrapulmonary blood vessels. Consequently, the mechanisms controlling blood vessel smooth muscle cell (SMC) contraction serve as potential sites for hypertension therapy. To explore these mechanisms, access to the intrapulmonary vessels is required and this is provided by the observation of a unique lung slice preparation with microscopy...

article

Back to the past: a new take on the timing of flowering plant diversification

Michael J. Sanderson

New Phytologist > 207 > 2 > 257 - 259

article

Confluence, synnovation, and depauperons in plant diversification

Michael J. Donoghue, Michael J. Sanderson

New Phytologist > 207 > 2 > 260 - 274

We review the empirical phylogenetic literature on plant diversification, highlighting challenges in separating the effects of speciation and extinction, in specifying diversification mechanisms, and in making convincing arguments. In recent discussions of context dependence, key opportunities and landscapes, and indirect effects and lag times, we see a distinct shift away from single‐point/single‐cause...

article

Tradeoff between robustness and elaboration in carotenoid networks produces cycles of avian color diversification

Alexander V. Badyaev, Erin S. Morrison, Virginia Belloni, Michael J. Sanderson

Biology Direct > 2015 > 10 > 1 > 1-22

Background Resolution of the link between micro- and macroevolution calls for comparing both processes on the same deterministic landscape, such as genomic, metabolic or fitness networks. We apply this perspective to the evolution of carotenoid pigmentation that produces spectacular diversity in avian colors and show that basic structural properties of the underlying carotenoid metabolic network are...

article

Evolutionary dynamics of leucine‐rich repeat receptor‐like kinases and related genes in plants: A phylogenomic approach

Tao Shi, Hongwen Huang, Michael J. Sanderson, Frans E. Tax

Journal of Integrative Plant Biology > 56 > 7 > 648 - 662

Leucine‐rich repeat (LRR) receptor‐like kinases (RLKs), evolutionarily related LRR receptor‐like proteins (RLPs) and receptor‐like cytoplasmic kinases (RLCKs) have important roles in plant signaling, and their gene subfamilies are large with a complicated history of gene duplication and loss. In three pairs of closely related lineages, including Arabidopsis thaliana and A. lyrata (Arabidopsis), Lotus japonicus...

article

Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity

Xiahui Tan, Michael J Sanderson

British Journal of Pharmacology > 171 > 3 > 646 - 662

Background and PurposeWhile selective, bitter tasting, TAS2R agonists can relax agonist‐contracted airway smooth muscle (ASM), their mechanism of action is unclear. However, ASM contraction is regulated by Ca²⁺ signalling and Ca²⁺ sensitivity. We have therefore investigated how the TAS2R10 agonists chloroquine, quinine and denotonium regulate contractile agonist‐induced Ca²⁺ signalling and sensitivity...

article

EvoMiner: frequent subtree mining in phylogenetic databases

Akshay Deepak, David Fernández-Baca, Srikanta Tirthapura, Michael J. Sanderson, more

Knowledge and Information Systems > 2014 > 41 > 3 > 559-590

The problem of mining collections of trees to identify common patterns, called frequent subtrees (FSTs), arises often when trying to interpret the results of phylogenetic analysis. FST mining generalizes the well-known maximum agreement subtree problem. Here we present EvoMiner, a new algorithm for mining frequent subtrees in collections of phylogenetic trees. EvoMiner is an Apriori-like levelwise...

article

Identifying a species tree subject to random lateral gene transfer

Mike Steel, Simone Linz, Daniel H. Huson, Michael J. Sanderson

Journal of Theoretical Biology > 2013 > 322 > Complete > 81-93

A major problem for inferring species trees from gene trees is that evolutionary processes can sometimes favor gene tree topologies that conflict with an underlying species tree. In the case of incomplete lineage sorting, this phenomenon has recently been well-studied, and some elegant solutions for species tree reconstruction have been proposed. One particularly simple and statistically consistent...

article

LOCATING EVOLUTIONARY PRECURSORS ON A PHYLOGENETIC TREE

Brigitte Marazzi, Cécile Ané, Marcelo F. Simon, Alfonso Delgado‐Salinas, more

Evolution > 66 > 12 > 3918 - 3930

Conspicuous innovations in the history of life are often preceded by more cryptic genetic and developmental precursors. In many cases, these appear to be associated with recurring origins of very similar traits in close relatives (parallelisms) or striking convergences separated by deep time (deep homologies). Although the phylogenetic distribution of gain and loss of traits hints strongly at the...

article

Exploring lung physiology in health and disease with lung slices

Michael J. Sanderson

Pulmonary Pharmacology & Therapeutics > 2011 > 24 > 5 > 452-465

The development of therapeutic approaches to treat lung disease requires an understanding of both the normal and disease physiology of the lung. Although traditional experimental approaches only address either organ or cellular physiology, the use of lung slice preparations provides a unique approach to investigate integrated physiology that links the cellular and organ responses. Living lung slices...

article

ESTIMATING DIVERSIFICATION RATES: HOW USEFUL ARE DIVERGENCE TIMES?

Joel O. Wertheim, Michael J. Sanderson

Evolution > 65 > 2 > 309 - 320

The dynamics of species diversification rates are a key component of macroevolutionary patterns. Although not absolutely necessary, the use of divergence times inferred from sequence data has led to development of more powerful methods for inferring diversification rates. However, it is unclear what impact uncertainty in age estimates have on diversification rate inferences. Here, we quantify these...

article

LARGE‐SCALE PATTERNS OF DIVERSIFICATION IN THE WIDESPREAD LEGUME GENUS SENNA AND THE EVOLUTIONARY ROLE OF EXTRAFLORAL NECTARIES

Brigitte Marazzi, Michael J. Sanderson

Evolution > 64 > 12 > 3570 - 3592

Unraveling the diversification history of old, species‐rich and widespread clades is difficult because of extinction, undersampling, and taxonomic uncertainty. In the context of these challenges, we investigated the timing and mode of lineage diversification in Senna (Leguminosae) to gain insights into the evolutionary role of extrafloral nectaries (EFNs). EFNs secrete nectar, attracting ants and...

article

A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness

Antonio Z. Politi, Graham M. Donovan, Merryn H. Tawhai, Michael J. Sanderson, more

Journal of Theoretical Biology > 2010 > 266 > 4 > 614-624

We present a multiscale, spatially distributed model of lung and airway behaviour with the goal of furthering the understanding of airway hyper-responsiveness and asthma. The model provides an initial computational framework for linking events at the cellular and molecular levels, such as Ca ²⁺ and crossbridge dynamics, to events at the level of the entire organ. At the organ level, parenchymal...

article

A Mathematical Analysis of Agonist- and KCl-Induced Ca2+ Oscillations in Mouse Airway Smooth Muscle Cells

Inga Y. Wang, Yan Bai, Michael J. Sanderson, James Sneyd

Biophysical Journal > 2010 > 98 > 7 > 1170-1181

Airway hyperresponsiveness is a major characteristic of asthma and is generally ascribed to excessive airway narrowing associated with the contraction of airway smooth muscle cells (ASMCs). ASMC contraction is initiated by a rise in intracellular calcium concentration ([Ca²⁺]_i), observed as oscillatory Ca²⁺ waves that can be induced by either agonist or high extracellular K⁺ (KCl). In this work, we...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Michael J. Sanderson

Evolution of l‐DOPA 4,5‐dioxygenase activity allows for recurrent specialisation to betalain pigmentation in Caryophyllales

Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma

The prevalence of terraced treescapes in analyses of phylogenetic data sets

Store‐operated calcium entry is required for sustained contraction and Ca²⁺ oscillations of airway smooth muscle

The relative contributions of store‐operated and voltage‐gated Ca²⁺ channels to the control of Ca²⁺ oscillations in airway smooth muscle

MRF Supertrees

Ca²⁺ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle Cells

Back to the past: a new take on the timing of flowering plant diversification

Confluence, synnovation, and depauperons in plant diversification

Tradeoff between robustness and elaboration in carotenoid networks produces cycles of avian color diversification

Evolutionary dynamics of leucine‐rich repeat receptor‐like kinases and related genes in plants: A phylogenomic approach

Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity

EvoMiner: frequent subtree mining in phylogenetic databases

Identifying a species tree subject to random lateral gene transfer

LOCATING EVOLUTIONARY PRECURSORS ON A PHYLOGENETIC TREE

Exploring lung physiology in health and disease with lung slices

ESTIMATING DIVERSIFICATION RATES: HOW USEFUL ARE DIVERGENCE TIMES?

LARGE‐SCALE PATTERNS OF DIVERSIFICATION IN THE WIDESPREAD LEGUME GENUS SENNA AND THE EVOLUTIONARY ROLE OF EXTRAFLORAL NECTARIES

A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness

A Mathematical Analysis of Agonist- and KCl-Induced Ca2+ Oscillations in Mouse Airway Smooth Muscle Cells

Filter options

Publication date

Content availability

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Michael J. Sanderson

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options