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Background: Opsonophagocytosis and complement-mediated Neisseria meningitidis killing after vaccination were investigated. Methods: Twelve seronegative healthy volunteers received one dose of polysaccharide A/C vaccine and were followed for 3 years. Ex vivo serum killing rates with polymorphonuclear cells (PMN) and/or complement were performed at 0, 1.5, 6, 12, 18, 24, 30 and 36 months. Results: High...
Background:. The aim of this study was to investigate the clinical and epidemiological characteristics of meningococcal disease in Catalonia (Spain) after vaccination with the polysaccharide vaccine. Patients and Methods:. Cases were collected by the Statutory Diseases Reporting System. Results:. 176 cases were reported, an overall incidence of 2.9/100,000 persons/year. 60% of cases occurred during...
AbstractSerogroup B has been the main cause of meningococcal disease in Spain since at least 1979, but in recent years an increase in the prevalence of infection due to serogroup C meningococci has been detected. In 1996, for the first time, most cases of meningococcal disease were caused by serogroup C strains. The sero/subtype of all serogroup C meningococci received from 1993 to June 1996 was determined,...
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