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Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP46–62, MBP124–139 and MBP147–170 (Xemys) suppressed experimental autoimmune encephalomyelitis in dark Agouti rats. The objective of this study was to assess the safety of Xemys in the treatment of patients with relapsing-remitting multiple sclerosis (MS) and secondary...
This paper presents a project the goal of which is to develop ASPIRE, a complete authoring and deployment environment for constraint-based intelligent tutoring systems (ITSs). ASPIRE is based on our previous work on constraint-based tutors and WETAS, the tutoring shell. ASPIRE consists of the authoring server (ASPIRE-Author), which enables domain experts to easily develop new constraint-base tutors,...
Research shows that emotions play an important role in learning. Human tutors are capable of identifying and responding to the affective states of their students; therefore, for ITSs to be truly affective, they should also be capable of tracking and appropriately responding to the emotional state of their users. We report on a project aimed at developing an affect-aware pedagogical agent persona for...
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