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Cell adhesion is implicated in a number of biological pathways such as angiogenesis, arteriosclerosis, chronic inflammatory diseases, and carcinogenesis. Chemokine receptor CXCR4 is often found aberrantly expressed on metastatic tumor cells. To investigate CXCR4 signaling in tumor cell adhesion, we stably overexpressed CXCR4 in hepatocellular carcinoma HepG2 cells. Regulation of CXCR4 in HepG2 cell...
Lymphatic vessel density (LVD) was recently considered important for spread of several malignant tumors. However, there are no reports describing the situation in cervical carcinoma. The purpose of this study was to investigate whether LVD could serve as a risk factor for nodal metastasis and recurrence of cervical carcinoma in 147 cases of stage I patients. Other questions were if depth of invasion,...
Prodigiosin, a bacterial metabolite, was reported to have immunosuppressive and anticancer activities. In this study, we investigated novel functions of prodigiosin about anti-metastasis and anti-invasion. Prodigiosin dose-dependently inhibited 95-D cells’ migration and invasion according to wound healing assay and the Transwell assay. The inhibitive effect could reach about 50% when cells were treated...
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