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The present work deals with localization of previously unknown polymerization sites of the fibrin DD-fragment. D-dimer we obtained has a pronounced inhibitory effect on fibrin polymerization (IC50 = 0.06 μM). The inhibitory effect of the D-fragment disappeared after reduction and carboxymethylation. However, polypeptide chains βDD (Bβ134-461) and γγDD (γ63-411)2 of the DD-fragment, isolated by preparative...