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Pyruvate, as an intermediate in the Krebs cycle, is an important source of energy for myocardium and improves contractility of normal, hypoxic, and postischaemic animal myocardium. We investigated the effect of intracoronary pyruvate in patients with congestive heart failure. Haemodynamic measurements were done in eight patients with dilated cardiomyopathy after two 15 min infusions of pyruvate...
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