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Although clinical differences in lung cancer between men and women have been noted, few studies have examined the sex dissimilarity using gene expression analysis.The purpose of this study was to determine the different molecular carcinogenic mechanisms involved in lung cancers in Japanese men and women.Patients who received surgery for stage I lung adenocarcinoma were included. RNA was extracted...
Expression of genes in the Rb-E2F signaling pathway is controlled by E2F transcriptional factors originally defined as molecules that bind to the promoter of E2 adenovirus. The E2F gene family consists of six members and is designated E2F16. The Rb-E2F signaling pathway is among the main regulators of the cell cycle, hence its importance in differentiation and oncogenesis. We document here up-regulation...
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